B (REG) CELLS IN HEPATITIS C VIRUS AND DIABETES / دور الخلايا التنظيميه B (reg) في الالتهاب الكبدي الوبائى Cومرضي السكري
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 10
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
ص/ فدوى على محمد - مؤلف رئيسي
الميكروبيولوجيا الطبية والمناعة
Over the last decade it has become evident that in addition to producing antibody, B cells activate the immune system by producing cytokines and via antigen presentation. In addition, B cells also exhibit immunosuppressive functions via diverse regulatory mechanisms. This subset of B cells, known as regulatory B cells (B regs), contributes to the maintenance of tolerance, primarily via the production of IL-10. Studies in experimental animal models, as well as in patients with autoimmune diseases, have identified multiple B(reg) subsets exhibiting diverse mechanisms of immune suppression. In this review, we describe the different B(reg) subsets identified in humans, and their diverse mechanisms of suppression in HCV and diabetic patients. Aims: The main objectives of the study are to identify the role of B (reg) in the hepatitis C virus infected patients and diabetes.
HYPOGLYCEMIC AND HYPOLIPIDEMIC EFFECTS OF GINGER IMPROVE KIDNEY FUNCTION IN OBESE MALE RATS / خفض مستويي الجلوكوز والدهون بواسطة الزنجبيل يحسن وظائف الكلى في ذكور الجرذان المسمنة
قطاع الدراسات الصيدلية / الكيمياء الحيوية
تخصص البحث : الكيمياء الحيوية
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 11
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
ص/ شيماء عبدالناصر عبداللاه - مؤلف رئيسي
الكيمياء الحيوية
Aside from being a social stigma, obesity is frequently associated with insulin resistance, in turn linked to development of type II diabetes, hypertension, hyperlipidemia, and atherosclerosis – the so-called metabolic syndrome.This study investigated the biochemical changes in serum urea and creatinine levels in obese male rats treated with aqueous ginger extract. Forty age-matched adult male wister rats (90-110) gm were divided into four groups of ten rats each: group I, Control group; group II: Obese group. group III: Low ginger dose (200 mg/kg body weight) treated obese group; group IV: High ginger dose (400 mg/kg body weight) treated obese group.The obese group exhibited hyperglycemia accompanied with increasing in serum levels of Triglycerides (TG), Low Density Lipoprotein Cholesterol (LDL-C), Total Cholesterol (TC) levels. On the other hand, there was a significant reduction in High Density Lipoprotein Cholesterol (HDL-C) level. Ginger was effective in lowering all previous mentioned biochemical parameters and HDL-C level was increased significantly. Serum urea and creatinine levels showed a significant increase in obese rats. Otherwise, obese rats treated with ginger at either dose revealed a significant decrease as compared to obese group. These results indicated that the hypoglycemic and hypolipidemic effects of aqueous ginger extract (200, 400 mg/kg/day) could ameliorate obesity related kidney dysfunction.
ENHANCEMENT OF LIPOSOMAL DRUG LOADING BY USING SUPERSATURATED DRUG SOLUTION / تحسين معدل تحميل الدوائي للليبوزومات عن طريق استخدام سوائل دوائية مشبعة
قطاع الدراسات الصيدلية / الصيدلة الصناعية
تخصص البحث : الصيدلة الصناعية
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ حسن تمام عبدالحميد - مؤلف رئيسي
الصيدلة الصناعية
Liposomes are used for systemic delivery of chemotherapeutic drugs to reduce their non-specific side effects. Liposomes can encapsulate hydrophilic and lipophilic drugs in the water compartment and the lipid membrane, respectively. However, typical drug loading capacity of liposomes by passive loading method is less than 1%. The low drug loading efficiency is problematic because it necessitates the use of a large amount of carrier materials that may cause undesirable biological effects. To increase drug loading in liposomes, weusedsupersaturated drug solutionswith gemcitabine (GEM) and doxorubicin (Dox) as examples. The prepared liposomes showed higher drug loading compared with passive loading, maintainedstabilityand provided sustained drug release for 48 hrs.
STEVIA IMPROVES THE ANTIHYPERGLYCEMIC EFFECT OF METFORMIN IN STREPTOZOTOCIN-INDUCED DIABETIC RATS: A NOVEL STRATEGY IN TYPE 2 DIABETES MELLITUS / ستيفيا تحسن تأثيرالميتفورمين المضاد للسكرى فى الجرذان المصابة بالسكرى تم احداثه بالستربتوزتوسن استيراتيجية جديدة لعلاج مرض السكرى الثانى
قطاع الدراسات الصيدلية / General
تخصص البحث : General
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
ص/ ليلى عاطف على - مؤلف رئيسي
الفارماكولوجى
Diabetes mellitus is a major health problem that threatens the whole world. According to WHO reports, the prevalence of diabetic patients in egyptis expected to increase from 2,623,000 in 2000 to be 6,726,000 in 2030. Metformin is the first line drug for type 2 diabetes mellitus, which can be used alone or in combination with other drugs. However, the concomitant use of metformin with stevia needs more investigation to clarify the role of this combination as a new strategy in type 2 diabetes mellitus. Type 2 diabetes mellitus was induced in rats by i.p. injection of STZ and NA. Animals were divided into five groups, each contains 8 rats. group I: negative control, group II: diabetic control received saline, group III: diabetic rats received 400 mg/kg/day stevia aqueous extract, group IV: diabetic rats received metformin 250 mg/kg/day, group V: diabetic rats received stevia 400 mg/kg/day + metformin 250 mg/kg/day. After 3 weeks blood samples were collected, animals were sacrificed and tissue samples were collected. Biochemical parameters including FBG, serum insulin, serum DPP-4, TC, TG, LDL, HDL, GSH and MDA were measured by colorimetric and ELISA methods. Both stevia and metformin significantly reduced FBG level. While serum insulin significantly increased. Serum DPP-4 was significantly reduced in all treated groups, concerning lipid profile, stevia and metformin significantly lowered TC, TG, LDLand increased HDL. Both stevia and metformin significantly decreased MDA and increased GSH compared to diabetic rats. In addition, stevia significantly improved the antidiabetic effects of metformin. Stevia has an antihyperglycemic effect and could increase the antidiabetic activity of metformin. DPP-4 attenuation, antioxidant and insulin-sensitizing effects may be involved in the antidiabetic action of stevia. Regarding lipid profile stevia showed hypolipidemic effect.
DEVELOPMENT AND charACTERIZATION OF NANO-STRUCTURED LIPID CARRIERS FOR TRANSDERMAL DELIVERY OF MELOXICAM / تطوير وتوصيف حوامل دهنيه متناهيه الصغر لتوصيل عقار الميلوكسيكام عبر الجلد
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 12
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
أ.د/ جيهان نبيل حسن فتيح - مؤلف رئيسي
الصيدلانيات
For transdermal delivery of meloxicam, nanostructured lipid carriers containing compritol as solid lipid, oleic acid as liquid lipid and different ratios of Pluronic F-68 were prepared. The prepared nanoparticles were characterized in terms of size, polydispersity index, zeta-potential and encapsulation efficiency. The average particle size, zeta-potential and encapsulation efficiency ranged from 134 to 491 nm, from -12.4 to -23.23 mV and from 35 to 70%, respectively. Furthermore, in vitro release for a number of selected formulations was performed using dialysis membrane in phosphate buffer saline. Drug release from free solution compared to release from nanostructured lipid carriers over a period of 48 hours was evaluated as well as release kinetic analysis was investigated. Moreover, stability of the selected formulation was studied at different time intervals. In addition, meloxicam-loaded nanostructured lipid carriers gel containing Carbopol-934 as a gelling agent was prepared. Moreover, anti-inflammatory activity of the prepared gel was evaluated using carrageenan-induced rat paw edema method. Meloxicam-loaded nanostructured lipid carriers gel showed a more sustained inhibitory effect compared to free meloxicam gel. Finally, toxicity of the prepared meloxicam-loaded nanostructured lipid carriers gel was evaluated using histopathological examination.
ENCAPSULATION OF ANTENNAPEDIA (PENETRATIN) PEPTIDE IN A POLYMERIC PLATFORM FOR EFFECTIVE TREATMENT OF INTRACELLULAR BACTERIA / تغليف الببتيد انتينابيديا (بينتراتين) في قالب بوليمري لعلاج فعال للبكتيريا داخل الخلايا
قطاع الدراسات الصيدلية / الصيدلة الصناعية
تخصص البحث : الصيدلة الصناعية
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 8
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ مروة جلال النجار - مؤلف رئيسي
الصيدلة الصناعية
Antimicrobial peptides (AMP) and cell-penetrating peptides (CPP) are two classes of peptides that share some structural and physicochemical similarities. Antennapedia or penetratin (ANT) is one of the most known CPPs, that was proven to have antimicrobial activity against certain strains of planktonic bacteria. ANT can enter the cells but has no activity against intracellular bacteria. This is attributable to the inability of the peptide to reach bacteria reside within cellular components as well as low delivery efficiency, due to loss of activity by proteolysis and poor specificity. The aim of this work is to develop a formulation that can effectively reach and attack intracellular bacteria. To achieve this goal, ANT was encapsulated in PLGA platform as nanoparticles with the size range of 500-1000 nm, which allows for selective uptake by macrophages where bacteria mostly reside. ANT was loaded with high loading efficiency (12.7%) inspite of high water solubility. ANT-nanoparticles (ANT-NP) had no cytotoxicity on J774a.1 macrophages and were readily taken up by macrophages as confirmed by fluorescence microscopy. Antibacterial activity of ANT-NP remains to be tested against different intracellular bacteria.
PERFORMANCE OF QUERCETIN-CHITOSAN GELS AS TOPICAL DELIVERY SYSTEMS / أداء الكورسيتين المحمل على هلاميات الكيتوزان كنظام لتوصيل الدواء الموضعي
قطاع الدراسات الصيدلية / الصيدلانيات
تخصص البحث : الصيدلانيات
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 9
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
د/ نيرمين السيد العراقى - مؤلف رئيسي
الصيدلانيات
This study was designed to evaluate suitability of chitosan polymer as a vehicle for topical delivery system. Quercetin (QUT) is a natural flavonoid, was incorporated into the gel vehicles in a concentration of 0.5% w/v. Gels were prepared with three different concentrations and different molecular weights of chitosan. Viscosity, drug release from prepared gels, permeation of drug through skin rat and anti-inflammatory activity of the drug using carrageenan induced rat paw edema method were studied. In-vitro release characteristics of the drug from different gels were carried out using dialysis membrane in phosphate buffer, pH 5.5. The release data were treated with various kinetic principles to assess the relevant parameters. The general rank order of QUT release was F1 > F4 > F2 > F3 > F5. The results also showed that, the release of drug from the prepared gels obeyed the diffusion model (Higuchi’s equation). The results revealed an inverse correlation between the drug release percent and the polymer concentration used. The permeation of drug through skin rat was carried out. The flux of drug is independent on the viscosity of the formulae. The results also showed a significant anti-inflammatory activity on rat paw edema.
MICROORGANISMS ASSOCIATED WITH DIABETIC FOOT ULCERS / الكائنات الدقيقة المصاحبة لقرح القدم السكري
قطاع الدراسات الصيدلية / الميكروبيولوجيا الطبية والمناعة
تخصص البحث : الميكروبيولوجيا الطبية والمناعة
Bulletin of Pharmaceutical sciences / / 42 - 30/12/2019
تاريخ تقديم البحث 25/12/2019
تاريخ قبول البحث 25/12/2019
عدد صفحات البحث 7
سارة يوسف محمد( Sarahyousef30@yahoo.com - )
ص/ هند ممدوح يوسف - مؤلف رئيسي
الميكروبيولوجيا الطبية والمناعة
Non-traumatic lower limb amputation is the most common devastating complication of diabetes, primarily due to diabetic foot ulcers (DFU) and diabetic foot infections (DFI). DFIs are predominantly polymicrobial and multidrug-resistant (MDR) and results in treatment failure. Aims: The main objectives of the study are to identify the microorganisms associated with diabetic foot ulers. Methods: This was a prospective study at a tertiary care hospital. One hundred patients over the age of 18, having chronic diabetic foot ulcer, and attending the diabetic foot outpatient department were included. Samples of pus were collected from deep wounds and processed using standard techniques for culture Results: One hundred samples were processed and 82 yielded positive cultures. Staphylococcus aureus was the predominant organism, followed by Pseudomonas aeruginosa. Then E coli, Klebsiella and Proteus
جميع البيانات التي يتم تسجيلها على النظام هي ملك للجهة صاحبة هذه البيانات
لا يتم الاطلاع على هذه البيانات من قبل مهندسي المركز إلا للضرورة القصوى ولغرض الدعم الفني وبالاتفاق مع الجهة صاحبة البيانات شفوياً أو كتابياً
لا يتم إعطاء أي بيان من بيانات النظام لأي فرد او جهة فرعية تنتمي للجهة صاحبة البيانات او لأي جهة أخرى إلا بموافقة كتابية من الجهة صاحبة البيانات
يمكن استخدام البيانات المسجلة على النظام بهدف عمل إحصائيات يستفاد منها فى قياس اداء النظام وكفاءة استخدامه من قبل مستخدميه
يتم تأمين جميع البيانات الخاصة بالنظام من خلال تأمين الحاسب الخادم الذي يستضيف البيانات ومن خلال تأمين انتقال البيانات بين جهاز المستخدم والحاسب الخادم وكذلك تأمين واجهة النظام التي يستخدمها المستخدم
كل مستخدم للنظام مسئول مسئولية كاملة عن كلمة المرور الخاصة به وعليه اتخاذ كافة الاحتياطات الممكنة حتى لا يستطيع أى شخص آخر الحصول عليها
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