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SECI Oncology Journal /
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اعداد الدورية
  SECI Oncology Journal /
  
 

[9002097.] رقم البحث : 9002097 -
Pattern and Outcome of primary Liver Tumors in Children: A 10 years report from single oncology center in Upper Egypt /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 6
  اشرف رضوان ابو طالب - مؤلف رئيسي
  Liver Tumors ,Hepatoblastoma,chemotherapy
  Background: Primary malignant liver tumors are uncommon in children with hepatoblastoma (HB) and hepatocellular carcinoma (HCC) are the most common. Objective: To study frequency, types, clinical presentation and outcome of liver tumors in children at Sohag Cancer Center (SCC). Materials and Methods: Data were retrieved from files of all cases with hepatic focal lesions presented to Pediatric Oncology Department at SCC from January 2005 to December 2014. Results: Among 48 children (26 males) presented to SCC with hepatic focal lesions 12 cases were non-neoplastic, 8 were metastatic hepatic deposits and 28 were primary hepatic tumors (20 HB, 3 HCC and 5 cases benign tumors). Primary liver tumors accounted for 1.55% of all pediatric tumors with HB being the most frequent (41.7%). Median age of HB cases at diagnosis was 2 years (range 1.5-6 years). PRETEXT stage II/III was reported in 17 cases while stages I and IV were reported in one and two cases, respectively. Nearly two-thirds of cases achieved complete or partial response after neoadjuvant chemotherapy. Complete tumor resection was achieved in 40% of cases. The median survival time for HB patients was 63 months with three years overall survival rate of 65%. Conclusion: Outcome of patients with HB was affected by both stage and histopathologic subtypes. Upfront chemotherapy allows complete surgical resection of initially unresectable primary tumors with improvement of survival outcome in such patients. As a developing country with high prevalence of infectious causes, nonneoplastic hepatic lesions should be taken in consideration during diagnosis of hepatic focal lesions.
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[9002098.] رقم البحث : 9002098 -
Multidisciplinary Management of Spinal Chordoma: Single Institution Study /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 10
  هشام حمزه - مؤلف رئيسي
  Spinal Chordoma ,bone neoplasm ,surgical treatment
  Introduction: Chordoma are rare, slowly growing, locally aggressive neoplasms of bone that arise from embryonic remnants of the notochord. This work aimed to evaluate the treatment results of a series of chordoma patients in our institute. More also, we try to clarify the importance of approaching such patients through a multidisciplinary team to maximize the oncologic and functional outcomes and to improve the patient’s quality of life. Patients and Methods: This study was conducted at SECI, surgical department during a period of 6 years duration. Patients were treated through multi-disciplinary team specialists of our cancer institute. Surgery and postoperative radiation therapy was offered to all patients. Results: Results involves 8 patients with an average follow-up interval of 38.5 months. We had four cases of local recurrence which was salvaged with re-surgery and/or adjuvant radiotherapy. We had no postoperative motor neurologic deficit, with an excellent sphincter control in all patients. The 3-year survival rate in this study is 87.5%. Conclusions: Multi-disciplinary treatment approach for chordoma is fundamental to improve overall outcomes. Surgery continues to be the primary modality in the management of chordoma. Rates of local recurrence, as well as survival, appear to be dependent on the achievement of negative surgical margins. Patients who relapse locally may have a poor prognosis but both radiation and surgery can be used as salvage therapy.
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[9002099.] رقم البحث : 9002099 -
Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for stage II or III breast cancer /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 7
  اسماء السيد عبد السلام - مؤلف رئيسي
  Breast cancer ,Concurrent radio-chemotherapy, Toxicity.
  Background: Radiation therapy after breast conserving surgery is a standard part of treatment for invasive breast cancer [12].. The authors found that delay in radiotherapy after surgery translated to increase in local recurrence. Methods: This study included included 46 female patients with stage II-III (31patient stage II and15 Stage III) breast cancer who underwent conservative surgery. Then received 4 cycles of (AC) of doxorubicin (60 mg/ m2) and cyclophosphamide (600 mg/m2) intravenously every 21 days followed by 4 cycles of paclitaxel (175 mg/m2) intravenously over3 h, with actual body weight used to calculate surface area. Paclitaxel was administered every 21 days beginning 21 to 28 days after the fourth cycle of AC. Radio- therapy was delivered concurrent with the first 2 cycles of paclitaxel, with Day 1 of radiation coinciding with Day 1 of Cycle 1 of paclitaxel. Results: Median age was 48 years: 60% of patients <50 years, most patients had stage II disease, and Grade II was the most common one. Invasive ductal carcinoma was reported in 94% and hormone receptors were positive in of p78.26% of patients. After median follow-up of 25 months, 2 year DFS was 93.5%, all patients were alive and ipsilateral local recurrence was reported in 2.2% only. 50% and 19.6% had Grade I and II acute skin toxicity respectively. At 12 months, grades (I) were reported as(26%) and no grade II skin toxicity was observed. telangiectasia, (34.7%) Grade I and completely disappeared after 24 month. Hyperpigmentation (6.5%, ) Grade I. and also completely disappeared after 24 month. (Subcutaneous fibrosis, and lymphedema (13%-19.6 ) respectively while at 24 months grade II only reported as 6.5%lymphedema. Acute radiation pneumonitis reported as 8.7%grade I and 4.3% grade II while chronic pulmonary fibrosis reported as 6.5% grade I and 2.2% grade II. Only 1 patients (8.%) developed more than 10% DROP in the left ventricular ejection fraction (LVEF). Conclusion: The results of our study suggest there are no increased acute or late toxicities with comparable DFS and local control rates affiliated. with the concurrent use of radiotherapy with paclitaxel as prescribed .Large randomized trials and long term follow up are needed to confirm these favorable findings .
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[9002100.] رقم البحث : 9002100 -
Prognostic Significance of Telomere Length in newly diagnosed chronic Lymphocytic Leukemia patients: measured By Flow- FISH technique /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 11
  شيماء جعفر - مؤلف رئيسي
  Chronic Lymphocytic , cellular homeostasis
  Background: Telomeres are specialized nucleoprotein structures present at the ends of human chromosomes, and are constituted of a tandem of repeats TTAGGG. Telomere length measurement has been assessed by many previous studies In B-Chronic Lymphocytic Leukemia patients (B-CLL). Telomere shortening was found to correlate with disease progression. The aim of our study was to measure Telomere Length (TL) by Florescence In-Situ Hybridization coupled with Flow-cytometer (Flow-FISH) technique in newly diagnosed B-CLL patients. Explore its prognostic significance, through determination of the relationship between TL; with disease stage, other prognostic marker such as CD38 & ZAP-70 expression and patient response to treatment. Methods: This study included 61 B-CLL patients in chronic phase and 67 normal healthy controls. Telomere Length (TL) was assessed in Lymphocytes by Flow-FISH technique.
Results: This work revealed a significant reduction of the Relative Telomere Length (RTL) in B-CLL patients than normal healthy control. RTL was significantly negatively correlated with CD38 and ZAP70 expression measured at patient diagnosis (p= 0.09& 0.017 respectively). Patients follow up was done by BMA after six months. We observed that patients who had higher TL, showed a better response to treatment (p> 0.001).
Conclusion: Telomere length may have a prognostic relevance in B-CLL cases.
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[9002101.] رقم البحث : 9002101 -
Radiofrequency Thermocoagulation of Bilateral Thoracic Splanchnic Nerves for the Management of Abdominal Cancer Pain /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 13
  فاطمة الزهراء حامد - مؤلف رئيسي
  Splanchnic nerves, radiofrequency thermocoagulation, upper abdominal cancers, pain
  Background: Abdominal cancers are aggressive with high mortality that causes severe abdominal pain and affects quality of life seriously. The disease is often resistant to analgesics, opioid and adjuvants but better response to neurolysis and pain management in the context of palliative care should be an early part of the overall therapeutic plan. Objective: To evaluate the efficacy and safety of radiofrequency thermocoagulation (TRF) of bilateral thoracic (Th) splanchnic nerves at the level of Th10 and Th11 in the management of upper abdominal cancer pain. Methods: It included 30 patients suffering from abdominal pain due to upper abdominal cancers for whom bilateral thoracic splanchnic nerves block (SNB) was performed by radiofrequency thermocoagulation at two level of Th10 and Th11. Visual Analog Scale (VAS) [0-10], 24 hrs oral morphine consumption, functional improvement (success rate) and complications were assessed and recorded before and after the block for 3 months follow up period. Results: The VAS scores and MST (Morphine sulphate tablets) doses showed significant reduction with TRF from the 1st day postprocedural up to the end of follow up with good success rate. No major complication was recorded. Conclusion: Radiofrequency thermocoagulation of both splanchnic nerves at level of Th10 and Th11 may offer a safe and effective technique for pain management in patients suffer from upper abdominal cancer. Trial registry: It was registered at www.clinicaltrials.gov at no.: NCT0306312.
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[9002102.] رقم البحث : 9002102 -
Stromal CD10 immunohistochemical expression in urothelial carcinoma of urinary bladder and correlation with clinicopathological parameters /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 10
  مروة تمام حسين - مؤلف رئيسي
  CD10, stroma, urothelial, stage, grade, papillary, bilharziasis
  CD10 is widely expressed in various tumor types and their surrounding cancer associated fibroblasts; and correlate with poor prognosis. In present study CD10 immunohistochemical expression in stromal fibroblasts surrounding urothelial carcinoma and its relationship with clinicopathological parameters were investigated. Patients and Methods: Formalin-fixed paraffin embedded tissue sections from 106 urothelial cancer specimens were stained with CD10 antibody using immunohistochemistry technique. Expression of CD10 in the stromal cells was then analysed to evaluate its association with different clinicopathological variables. Results: Stromal CD10 expression was significantly associated with each of high grade (P<0.001), invasive tumor, advanced stage (P<0.001), squamous differentiation of tumor cells (P=0.02) and papillary architecture (P<0.001). There was no significant association between stromal CD10 expression and, and patient age, sex and tumor size.
Conclusion: Increased expression of CD10 in cancer associated fibroblasts was strongly correlated with tumor progression and invasion
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[9002103.] رقم البحث : 9002103 -
Serine Protease Inhibitor Kazal type 1 (SPINK1) expression in Colorectal cancer: Immunohistochemical study /
تخصص البحث : General
  SECI Oncology Journal / / vol.5 - 2017
  تاريخ تقديم البحث 08/10/2018
  تاريخ قبول البحث 08/10/2018
  عدد صفحات البحث 9
  شيماء حسن شعبان - مؤلف رئيسي
  Serine Protease Inhibitor Kazal type 1 SPINK1, Tumor Associated Trypsin Inhibitor TATI, colorectal Cancer CRC
  Background: Serine protease inhibitor kazal type 1 (SPINK1) was highly expressed in many cancer types and in colon, SPINK1 was involved in inflammation-induced colon cancer, proliferation and carcinogenesis. In this study, SPINK1 protein expression in colorectal cancer specimens was evaluated and correlated its expression with clinicopathological variables.
Material and methods: Formalin-fixed paraffin embedded tissue sections from 87 colorectal cancer specimens were stained with SPINK1 antibody using immunohistochemistry technique. Expression of SPINK1 was then analysed to evaluate its association with clinicopathological variables.
Results: High SPINK1 protein expression was detected in 75 (86.2%) of CRC specimens and was significantly associated with lymph-vascular invasion (p < 0.001), and lymph node metastasis (p = 0.005), and advanced clinical stage (p= 0.003). Conclusion: High SPINK1 protein expression is associated with lymph-vascular invasion and lymph node metastasis in colorectal cancer suggesting its role in invasion and metastases.
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