عرض تفاصيل البحث
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| Synthesis, thermal, molecular structure, molecular docking and biological study of 1-(2-thiazolylazo)-2-naphthalenol with Zn (II), Cd (II) and Pb (II). / | |||||
| تخصص البحث : Medicine | |||||
| Mansoura Journal of Environmental Sciences - Egypt JOESE / Vol.46 No.1 - March 2017 | |||||
| Dina Ahmed Khedr - مؤلف رئيسي | |||||
| Alaa S. Amin | |||||
| Mostafa A. Hussien | |||||
| Keywords: 1-(2-thiazolylazo)-2-naphthalenol (TAN), IR, 1H NMR, Molecular docking, Biological activity. | |||||
| Abstract Thiazolylazo dye derivatives and their metal complexes have been synthesized the reaction of Zn (II), Cd(II) and Pb(II) ions with 1-(2-thiazolylazo)- 2-naphthalenol (TAN) in 1:2 (metal-to-ligand) molar ratio. The ligand and their metal complexes were characterization by elemental analysis, (IR and 1H NMR spectra), furthermore thermal analysis (TG and DTG) systems. The kinetic and thermodynamic parameters, for example, E?, ?H?, ?S? and ?G? are ascertained from the DTG curves. The complexes are suggested to have the general formula [M(L)2].nH2O; M= Zn(II), (n= 2)and M=Cd(II), (n=4), [Pb2(L)(NO3)4.H2O].H2O. Molecular docking was utilized to predict binding between azo compounds with the receptor of prostate cancer 2q7k-Hormone. The biological activity of the ligands and their metal complexes was assessed against a few sorts of Bacillus subtilis, Streptococcus pyogenes, Staphylococcus aureus (Gram positive), Escherichia coli, Pseudomonas aeruginosa, Erwinia carotovora (Gram negative) and antifungal activity against candida. |
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