الفهرس Only 14 pages are availabe for public view
 |  | from | 141 |  |  |
| | | from | 141 | | |
Abstract
Human Parvovirus B19(HB19) a single stranded DNA virus is a global and common infectious pathogen in humans .transmission of infection accours via respiratory route ,though blood –derived products administered parenterally or through vertical transmission .the virus has tropism for rapidly diving erythrocyte precursors
Usually infectin by Human Parvovirus B19 is mild &self limiting in healthy children with hemoglobinapathy or hemolytic anemia the condition may be critical causing aplastic crisis due to short life span of red blood cells ,also immunocompromized patients may develop serious complications like myocardities encephalitis &hepatitis (Brown et al.,2002)
ALL,the most common canser accruing in children was frequently described in association with HB B19
This study investigated this association .it compared the presence of HP B19 DNA inCSF of 20ALL cases at time of dialgnosis before ite disappearance by the developing immune system and it’s presence in CSF of 10 age and sex matched controls
The study showed the presence of HP B19 DNA in CSF of 4 ALL cases (20%) but the neither of the control group
It showed that cases of ALL positive for HP B19 DNA tend to younger than ALL cases negative for HP B19 DNA
They were of common pre-B immunophenotype .they all had lower Hb ,platelet and white blood cells count ,this may be due apoptotic effect of the NSI protein of the HP B19 virus