الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Acute myeloid leukemia is the most common form of acute leukemia in adults. According to Globocon 2020, AML is ranked among the top 10 cancers affecting the Egyptian population with a slightly higher incidence in male population.
Acute myeloid leukemia is an aggressive disease with malignant transformation that occurs in HSCs or in the early progenitors, characterized by increased rate of proliferation, reduced apoptosis and a block in cellular differentiation. These lead to accumulation of blast cells in the BM at the expense of normal RBCs, WBCs and platelets.
The disease is characterized by an abrupt onset of symptoms which rapidly progresses over a period of few weeks. Acute myeloid leukemia is a disease of complex heterogeneity characterized by a huge range of genetic abnormalities. FAB classification is used to classify AML into subtypes from M0 to M7 depending on cell morphology. According to CSC theory, LSCs are thought to be the primary cause of leukemia initiation, progression, drug resistance and disease prolapse.