الفهرس 
Diabetes MellitusOnly 14 pages are availabe for public view
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Abstract
Diabetic retinopathy is associated with endothelial dysfunction and chronic inflammation and an adjuvant risk factor contributing to inflammation state, such as increased levels of plasma homocysteine, may accelerate or aggravate the development or progression of diabetic retinopathy.
The aim of this study was to investigate plasma homocysteine as a screening and diagnostic indicator for assessing diabetic retinopathy (DR) risk in patients with diabetes mellitus.
This was an observational study which was conducted on 90 diabetic patients at diabetes outpatient clinic at Ain Shams University Hospital, over period of 8 months from April 2022 to December 2022 to investigate plasma homocysteine as a screening and diagnostic indicator for assessing diabetic retinopathy (DR) risk in patients with diabetes mellitus.
For all the participants, the following investigations were done:
• FBS, PPBS (mg/dl).
• HBA1C (%).
• Estimated GFR (mL/min/1.73m2).
• Serum plasma homocysteine (Umol/L).
• Albumin/creatinine ratio (mg/g).
• Fundus examination with indirect ophthalmoscopy.
Statistical analysis of this study reveals that:
• There was a high statistically significant difference between the studied groups regarding (age of the patient and duration of diabetes mellitus) also clinical data (HTN, SBP and DBP) also laboratory data (FBS, HBA1C, eGFR and albumin /creatinine ratio).
• There was a high statistically significant difference between the studied groups regarding homocysteine level.
• There was positive correlation found between homocysteine level and (age, duration of diabetes, HTN, oral antidiabetics, HbA1C, FBG, eGFR and ACR).
• There was no statistically significant difference between the studied groups regarding (gender, smoking and BMI).
• There was no correlation between homocysteine level and (gender, smoking, BMI and 2hpp).