الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
H
epatocellular carcinoma HCC is now the sixth most common cause of cancer worldwide. The second leading cause of cancer death after lung cancer in men is HCC.
The most frequently used screening tests for HCC patients are hepatic ultrasound (US) with or without assessment of alpha-fetoprotein, but the diagnostic value of AFP is recently challenged due to its low sensitivity and specificity.
So the aim of this study was to evaluate the role of mac 2 as a diagnostic marker in HCC Egyptian patients.
The study was carried out on 70 Egyptian patients:
group A (HCC): 35 patients with Hepatocellular carcinoma, age more than 18.
group B (Cirrhotic): 35 patients with liver cirrhosis without Hepatocellular carcinoma, age more than 18.
For all participant in this study, full clinical assessment by history and physical examination in addition to laboratory hematological and biochemical assessment and confirmation of HCC diagnosis was done by triphasic CT on the abdomen, We assessed serum mac 2 in all study participant.
In this study, we found that there was no significant difference between group A (HCC) and group B (cirrhotic) regarding (age, gender, smoking, DM, HTN).
We found that cut off point for Mac-2 level to detect cases HCC was found >1059 with sensitivity of 74.29%, specificity of 65.71% and area under curve (AUC) of 74%.
Being statistically significant higher in HCC group more than both cirrhotic group Mac 2 was found slightly elevated in cirrhotic patients compared to HCC, suggesting that MAC 2 level increase in liver damage, however the significance was much lower than that from a comparison between the cirrhosis and hcc groups.
The results showed, There was no significant correlation between mac2 and (age, WBS, platelet, AST, albumin, INR, child score) among both HCC group and cirrhotic group.
While there was statistically significant positive correlation between mac2 and (HB, Na, total and direct bilirubin, ALT, AFP, MELD) among HCC group.
While there was statistically significant negative correlation between MAC2 and (HB, K, total bilirubin, AFP) among cirrhotic group.
MAC 2 is more sensitive than AFP in differentiation between HCC and cirrhoitic patients but AFP is more specific.
The presence of (mac-2) in blood, is a biomarker of early stages of HCC.
Mac 2 is a promising serum tumor marker for HCC diagnosis.