الفهرس 
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Abstract
Objective: To assess the relation between plasma Visfatin and fibroblast growth factor-21 (FGF21) with each other, and their relations with the metabolic disturbances risk factors in a sample of prepubertal children.
Methods: This study was a case-control study that included 111 children; with age ranged between 6 up to 10 years: 45 males (with mean age 8.74 ± 1.60 years) and 66 females (with mean age 8.78 ± 1.73 years). Full History taking, general clinical examination, blood pressure measurement, anthropometric measurements (body weight, height, BMI, waist and hip circumferences) and biochemical parameters (fasting blood glucose, insulin, lipid profile, Visfatin and FGF-21) were measured, and calculation of HOMA-IR was done.
Results: Examining the sex differences in all the studied variables: age, clinical, anthropometric parameters and laboratory investigations were insignificant. So, the analysis was completed as one sample; without sex differentiation. Spearman’s correlation analysis revealed that FGF-21 and Visfatin had highly significant positive correlations with each other (p<0.001). Serum FGF-21 only had highly significant positive correlations with BMI, WC and HC (p=0.003, 0.000, 0.003) respectively, and significant positive correlations with SBP and DBP ( p=0.013, 0.012) respectively. Both FGF-21 and Visfatin had insignificant correlations with the laboratory investigations (FBG, insulin, HOMA-IR and lipid profile).
Conclusion: Among the Egyptian children, there were significant positive correlation between serum FGF-21 and Visfatin. However, neither of them had significant correlation with the metabolic disturbances risk factors among this studied age group.