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Abstract
The effect of gamma (y) irradiation on two antibiotics (amoxicillin and cefaclor) were studied. Antibiotics in solid state were subjected to irradiation sterilization by(y) at 25 kGy in atmospheric air at room temperature and afterwards they were subjected to some microbiological and analytical determination to check their stability. The results showed that the majority of initially unirradiated compounds had a slight degree of contamination with Bacillus and Micrococcus genera. All irradiated samples were free from any bioburden and their biological activity was mostly preserved, EPR (Electron Paramagnetic Resonance) results showed formation of free radicals. The analytical determination (FT/IR, UV, mass spectroscopy, and Melting point) results proved that the antibiotics analyzed were radio stable and could be sterilized by irradiation with a dose of 25kGy, without any detrimental effect on their properties and antibacterial activity