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Abstract
Beta - 2 microglobulin (v2M) is responsible for transmission of viral antigens on the surface of cells as part of HLA complex. Normal serum levels are less than 3æg / ml. It increases in inflammatory and malignant conditions including HCV infection. Determining the concentration of serum v2M levels in patients with HCV related chronic hepatitis, cirrhosis, and hepatocellular carcinoma and correlate the results with clinical parameters for disease progression. In this analytical cross sectional study 92 participants were included in 4 equal groups: group (1) non cirrhotic chronic HCV, group (2):HCV related liver cirrhosis, group (3): HCC on top of HCV, group (4): healthy controls. History taking, clinical examination ,routine labs, and US were done to all patients. group specific inclusion criteria: PCR, metavir score for group (1) patients. CT and AFP for group (3) patients. v2M levels were measured in serum by ELISA. Quantitative variables presented by number and percent were compared by chi - square or fisher’s exact test