الفهرس 
Title : effect of pulsed electromagnetic field on oxidative stress in paracetamol-induced toxicity rat model
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Abstract
To evaluate the efficacy of extremely low frequency pulsed electromagnetic field
(ELF-PEMF) on oxidative stress and renal function following Paracetamol induced toxicity rat
model by measuring biochemical markers of oxidant-antioxidant (superoxide dismutase, nitric
oxide), lipid peroxidation (malondialdehyde) and renal function test (serum urea and creatinine
levels).
Methods. 22 rats of 10±2 weeks old received a single dose of Paracetamol (PC) (2 g/kg)
Paramol® (500 mg/tablet) and divided into two groups randomly. group A (control group):
received only PC dose and group B (PEMF group): were exposed to ELF-PEMF at four
frequencies (1, 10, 20, and 40 Hz) in three series, the transition period of each pulse train is 4
min, followed by 1 min of rest, each series is performed for 20 min, for a total of 60 min/daily
applications for 4 weeks. Assessment was done by measuring oxidant-antioxidant markers
(superoxide dismutase, nitric oxide) lipid peroxidation (malondialdehyde) and renal function test
(serum urea and creatinine), first after the induction of PC toxicity, then after 4 weeks at the end
of the experiment.
Results. This trial revealed a significant decrease in both oxidative markers (malondialdehyde
and nitric oxide) in group B in comparing to group A, with a percentage of change (23.23%)
(19.65%) in group B and (1.46%) (2.06%) in group A, respectively. A significant increase in
antioxidant enzyme (superoxide dismutase) in group B in comparing to group A, with a
percentage of change (19.65%) in group B and (1%) in group A, a significant decline in both
serum creatinine and urea levels in group B in comparing to group A, with a percentage of
change (30.54%) (17.52%) in group B and (1.9%) (1.3%) in group A, respectively.
Conclusion. Pulsed electromagnetic field had an obvious improvement in antioxidation capacity
and kidney function.