الفهرس 
II-Synthsis of 2,7-NaphthyridineOnly 14 pages are availabe for public view
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Abstract
Synthesis and discussion of compound (III): The condensed thiopyrano compound 3-
amino-7-methyl-1-thioxo-5,6,7,8-tetrahydro-1H-thiopyrano[3,4-c]pyridine-4-carbonitrile
(II) was synthesized in high yields via one-step condensation of 1-methylpiperidin-4-one
with malononitrile and CS2 in triethyl amine presence to give the thiopyrano Composition
(II) which react with morpholine in rearrangement reaction to produce 3-mercapto-7-
methyl-1-morpholino-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile (III). Scheme
1.
3-mercapto-7-methyl-1-morpholino-5,6,7,8-tetrahydro-2,7-naphthyridine-4-carbonitrile
(III) reacted to α-halogenated carbonyl compounds with sodium acetate refluxing ethanol
to give s- alkylated mercapto compounds (IVa-i) that were cyclicated by Thorpe-Ziegler
to tetrahydrothieno[2,3-c][2,7]-naphthyridino compounds (V a-i) upon heat in ethanol
and sodium ethoxide. Compounds (V a-i) can be obtained directly from (III) by
refluxation in the presence of potassium carbonate with α-halogenated carbonyl
compounds (Scheme 2). Scheme 3.