الفهرس 
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Abstract
The present work was performed to study the protective role of resveratrol against d-galactose-induced renal damage in male albino rats. This study was carried out on 40 adult male albino rats (weighing 150 - 200g). All rats were housed under a standard animal laboratory room temperature with free access to water. All procedures were subjected to ethical committee of Tanta University. The rats were divided into four groups (10 rats each) as the following: - • group I (Control group): animals were injected with 0.9% saline subcutaneously once daily for 8 weeks. • group II (D-gal group): animals received 120 mg/kg D‐gal in 0.9% saline subcutaneously every day for 8 weeks. • group III( Res group): animals received resveratrol at a dose of (50 mg/kg/day) via oral gavage for 8 weeks. • group IV( D-gal + Res group ): received D-gal subcutaneously and oral resveratrol daily for 8 weeks in the same doses as in groups II and III. At the end of experiment, all animals will be scarified by cervical decapitation under general anesthesia to collect blood samples and take sample of renal tissue. For measuring the following parameters: • Serum Creatinine. • Serum BUN. • Serum TNF alpha. • Renal Malondialdehyde (MDA). • Renal Glutathione Peroxidase (GPx). The achievement gained in this study could be summarized as follows: Res group (III) showed insignificant changes in the serum creatinine and BUN levels while it showed significant decrease in the renal MDA level together with significant increase in the renal GPx level as compared to the Control group (I). However, D-gal group (II) showed significant increase in the serum creatinine level, serum BUN level, serum TNF-α level and the level of renal MDA with significant decrease in the renal GPx level as compared to the Control group (I) and Res group (III). However, the D-gal + Res group (IV) that received both D-gal 120 mg/kg/d with resveratrol 50 mg/kg/d showed significant decrease in the serum creatinine, serum BUN, serum TNF-α levels and the level of renal MDA with significant increase in the renal GPx level as compared to the group that received D-gal alone (II).