الفهرس 
MIGRAINEOnly 14 pages are availabe for public view
 |  | from | 172 |  |  |
| | | from | 172 | | |
Abstract
Migraine is a common, disabling neurological disorder. Its high prevalence and socio-economic and personal impact was documented by many epidemiological studies (Olesen, 2018).
It has been recognized as the second overall cause of disability (both genders, all ages) according to Global Burden of Disease (GBD) study 2018 (Steiner et al., 2020), the first leading cause of disability in those aged less than 50 years (Arzani et al., 2020).
The gut-brain axis is one of the important factors that affect the pathophysiology of migraine (Dodick, 2018a). Studies suggest that how the gut and the brain interact in patients with migraine is influenced by multiple factors such as gut microbiota profile, inflammatory mediators (IL-1β, IL-6, IL-8, and TNF-α), neuropeptides and serotonin pathway, stress hormones and nutritional substances, with the composition of the gut microbiota having a major role in gut-brain axis (Arzani et al., 2020).
Our case control study included 10 chronic migraine patients and 10 healthy controls who were recruited from headache and general neurology clinics in Ain-Shams University hospitals. Its main aim was to test for the presence of difference in intestinal microbiota profile between both groups, subjects were subjected to full neurological history and examination, full headache sheet evaluation used in headache clinics and a stool sample analysis using 16s rRNA next generation sequencing by Illumina platform.
As regards non microbiota-related results the PHQ4 absolute value (4.3 ± 2.7 for cases, 1 ± 0.8 for controls) and severity (60% of cases moderate, 100% of cases severe) which showed statistically significant difference between both groups.
Regarding the intestinal microbiota results, alpha and beta diversity didn’t differ significantly among the chronic migraine and control groups, also our results highlighted highlight that the most common phylum was firmucites, one of the common class and order in patients was Clostridia Clostridiales Lachnospiraceae, Clostridia Clostridiales Ruminococcaceae while the most abundant order, family and genus respectively in controls were Clostridiales Lachnospiraceae Roseburia, Clostridiales Lachnospiraceae Howardella, Bacillales Family_XI Gemella which has no statistically significant difference.