الفهرس 
REVIEW OF LITATUREOnly 14 pages are availabe for public view
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Abstract
Obesity is the greatest public dietary issue nowdays, and it one of the greatest severe public health issues in developing countries. It’s prevalence and severity in childhood are growing.
Obesity in childhood is a risk indicator for many diseases in the future . Children whose obesity continues into adulthood have a considerably amplified risk of T2D, hypertension, dyslipidemia, and carotid-artery atherosclerosis than do adults who were never suffering with obesity.
SHBG is the major sex hormone carrier protein in serum, it’s primary function is to deliver sex-related hormones to the intended tissues and moderates the quantity of unbound sex hormones that can get inside of the target cells. Low serum SHBG concentrations in overweight persons consudered a predictor for metabolic syndrome and a predictor of the risk T2D and CVD.
Peripheral blood was obtained from 10 healthy non obese their BMI is more than 5th percentile to less than the 85th percentile as a control group and 30 total patients group their BMI more than 85th percentile divided into two sub groups, 15 over-weight group their BMI >85 th but < 95 th percentile and 15 obese group their BMI ≥ 95 th percentile, age ranged from 12 to 19 years. For every blood sample complete blood picture, liver and kidney function test , lipid profile, HbA1c, fasting plasma glucose , fasting plasma insulin, HOMA-IR ,CRP , Testosterone, adipokines (leptin and resistin) and sex hormone-binding globulin (SHBG) were determined.
The result obtanied from each group of obesity were compared with other groups and with the control group on non obese adolescents.
In conclusion data obtained from this study suggest that negative association between SHBG and BMI can be considered as predictor for some metabolic syndrome and risk factor for cardiovascular disease.