الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Chronic kidney disease is a major global health problem with an increasing prevalence .By 2040, it is estimated that CKD will have become the fifth leading cause of death. Several hundred genes are currently known to contain mutations that can cause single gene disorders with a kidney phenotype, as well as dozens of genetic loci in which common genetic variants are associated with kidney function in the normal range and with complex kidney diseases. So, This study aimed to investigate the effect of eNOS gene in the 27 bp VNTR of intron 4 polymorphism, MTHFR gene C677T (rs1801133) and MnSOD Val16Ala (rs4880) gene polymorphisms on the genetic susceptibility of chronic kidney disease among Egyptian Patients.
from this study, we can conclude that:
The eNOS and MTHFR gene polymorphisms were found to be associated with the development of CKD among Egyptian patients. In the contrast, the present study revealed that no statistically significant differences were found among the CKD, ESRD, and control groups as regards the SOD2 genotypes (p=0.064).
This is the first study that explores a significant association with NOS3 (rs 2070744) gene polymorphism within the increased risk of ESRD and CKD among Egyptian patients. However, some research did not detect a link, therefore the findings are debatable. More research in different populations is needed to find potential genetic risk factors for CKD.