الفهرس 
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Abstract
Diabetes mellitus is a chronic disease that occurs either when the pancreas does not produce enough insulin or when the body cannot effectively use the insulin it produces. Insulin is a hormone that regulates blood sugar. In 2017, 425 million people had diabetes worldwide, up from an estimated 382 million people in 2013and from 108 million in 1980. Accounting for the shifting age structure of the global population, the prevalence of diabetes is 8.8% among adults, nearly double the rate of 4.7% in 1980. Type 2 makes up about 90% of the cases. Some data indicate rates are roughly equal in women and men, but male excess in diabetes has been found in many populations with higher type 2 incidence, possibly due to sex-related differences in insulin sensitivity, consequences of obesity and regional body fat deposition, and other contributing factors such as high blood pressure, tobacco smoking, and alcohol intake
When the glucose concentration in the blood remains high over time, the kidneys reach a threshold of reabsorption, and the body excretes glucose in the urine (glycosuria) that cause Diabetic nephropathy on the long run duration. Diabetic nephropathy, also known as diabetic kidney disease, is the chronic loss of kidney function occurring in those with diabetes mellitus. Diabetic nephropathy is the leading causes of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally. Inflammation plays a critical role in the pathogenesis of DN so that inflammatory cytokines were profiled in this study.
The present study aimed to profile serum IL-17 and IP-10 levels and IL-10 in type 1 and type 2 diabetic patients’ and to correlate their levels with the inflammatory markers and renal nephropathy.
To accomplish the aim of this study, we select in this study 72 diabetic patients who were divided into two groups. group 1 included diabetic patients without complications with an albumin creatinine ratio of less than or equal to 30, while group 2 included 36 diabetic patients with an albumin creatinine ratio of more than 30 and 28 subjects as a control group. Two diabetic groups were divided into two subgroups according to C peptide levels type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). Serum samples were collected and tested for C reactive protein, IL 17, IL 10, and IP 10 by ELISA
The goal of this study evaluated the clinical significance of inflammatory cytokines in Diabetic nephropathy patients than normal control and diabetic without complications
The results showed that the IL‑17 and IP‑10 levels were significantly increased in type 2 diabetic nephropathy patients compared with controls, but IL‑10 levels were significantly increased in diabetic patients with T2DM compared with controls and T1DM. There was a significant increase for nephropathy T1DM patients than non‑nephropathy patients. In conclusion, monitoring of cytokines helps evaluate the immune status inflammation of diabetic nephropathy patients.