الفهرس 
SYSTEMIC LUPUS ERYTHEMATOSUS (SLE)Only 14 pages are availabe for public view
 |  | from | 163 |  |  |
| | | from | 163 | | |
Abstract
SUMMARY
S
ystemic lupus erythematosus (SLE) is a chronic autoimmune inflammatory disease with unknown etiology which has diverse clinical manifestation, course of illness and prognosis.
Neutrophil death and formation of NETs and NETosis play a fundamental role in SLE pathogenesis. NETosis may induce the production of antiCarP antibodies in SLE patients.
Joint involvement is one of the most common manifestations in patients with SLE, with a prevalence ranging from 69 to 95%. This significantly influences the patients’ quality of life, may lead to disability and impaired functional performance in daily activities. The prevalence of US abnormalities in asymptomatic patients with SLE varied from 3% to 58% that could be missed by routine physical examination and radiographical studies.
In this work we aimed to measure the serum Anti-CarP level in SLE patients and to investigate its role in association with disease activity and severity.
The present study was conducted on 40 SLE female patients and 40 healthy female controls. SLE diagnosis was performed according to the new ACR/ EULAR 2017 classification criteria of SLE. The activity of joint involvement was assessed by S/T ratio, disease activity was assessed by using SLEDAI-2K score, disease severity was assessed by KATz score. Each patient underwent the following lab investigations CBC, ESR, CRP, Anti-dsDNA, ANA, C3 and C4 serum level, RF, Anticcp and anti-carP by ELISA kits. Musculoskeletal ultrasonography was used to assess articular involvement of both hands and wrists joints.
In the present study, we add a piece to the puzzle suggesting that anti-CarP may be involved in the pathogensis of SLE as it was statistically significantly higher in patients than healthy controls. Also, anti-carP was positively correlated with disease activity, severity and lupus nephritis severity. However there was no correlation between ultrasonographic findings in hand and wrist joints and anti-carP levels. So, further work for assessing Anti-carP antibodies as a marker of arthritis is needed.