الفهرس 
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Abstract
Background: Subclinical left ventricular (LV) systolic dysfunction has been proved in type 2 diabetes mellitus (DM). There is lack of uniform data on systolic myocardial function in type 1 DM. The effect of type 1 diabetes mellitus (T1DM) on myocardial function is still controversial. T1DM is associated with at least 10-fold increase in cardiovascular disease as compared with an age matched non-diabetic population.Objective: To evaluate LV function with 2D speckle tracking echocardiography (2D STE) in adult type 1 diabetic patients.Patients and methods: This study included Two groups control group (15 patients) and T1DM patients group ( 30 patients ) without known cardiovascular disease, have never smoked. All the studied population was subjected to full history taking, detailed clinical examination, 12 lead ECG, laboratory investigations and echocardiography.Results: As regards indices of LV systolic function, diabetic patients in our study had significantly lower LV GLS despite similar LV EF compared to controls with statistically significant positive correlation between duration of DM and GLS (%) , The longer duration of diabetes; the more affection of GLS (%). LDL-C was increased and HDL was decreased among diabetics with statistically significant difference. As Regarding glycaemic control and duration of DM (years) in our study mean FBG and HbA1c were statistically higher among patients group.Conclusion: In this study, we have demonstrated that Subclinical impairment of systolic global LV function in young T1DM patients without evident cardiovascular disease, which can be identified as a reduction of global LS. LDL was an independent predictor of decreased LV LS. Glycemic control represented by HBA1c and diabetes duration as an independent predictor of peak systolic GLS which was significantly reduced in diabetic patients compared to controls.