الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
In the current thesis, two vital herbal actives namely; Baicalin (BCL) and Andrographolide (AG) was incorporated into the novel lipoidal chylomicron-mimcking nanosystem; Emulsome (EML) in order to improve their oral bioavailability as well as targeting the lymphatic system; the intended cite of their pharmacological action for the treatment of lymphoma.
< EML is a natural biodegradable and biocompatible table vesicular system that are formulated in the absence of any ionic or non-ionic synthetic surfactants or co-surfactants in the outermost layer.
<They can vastly increase the solubility of poorly soluble drugs with high entrapment efficiency and sustained drug release.
EML could significantly provide a prolonged action at comparatively low drug doses. Consequently, reducing the toxicity problem due to complimentary localization of the drug in target cells. Moreover, EML persist the development of multi drug resistance which cause drug efflux and thus enhance oral bioavailability.
The fact that EML mimic natural chylomicron in their structure, reveals their potential to be absorbed through intestinal lymphatic transport after oral administration.
Thus, they increase the oral bioavailability of the loaded actives via bypassing the first pass hepatic metabolism and targeting the lymphatic system.
The work in this thesis was divided into three different chapters.