الفهرس 
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Abstract
Canola (Canadian oil, low acid) obtained through classical breeding of rapeseed to reduce its anti-nutritional content to improve oil quality. It is a promising source of a new protein. It can substitute soybean due to its great nutritional value, which is expressed in well-balanced amino acids. Probiotics are live microbial feed supplements used as safe alternatives to antibiotics as growth promoters in animal feeding which improve their host health and intestinal balance, enhance productive performance and meat quality. Our present study was carried out to evaluate the effect of introducing some biotechnology applications in growing rabbit diet as the genetically modified rapeseed (canola) and probiotic through detection of some selective hematological, biochemical parameters, oxidative stress markers, and antioxidant enzymes in liver homogenate, and also through evaluation of some immunological parameters. This work was conducted on 120 mixed-sex California rabbits at weaning age (618 g average body weight). Rabbits were divided randomly into 8 groups as follow: non supplemented control rabbits (Cont), rabbit supplemented with 1.0 g/kg probiotic (PG), rabbit supplemented with 15% canola seed (CS), rabbit supplemented with canola seed and probiotic (CS+PG), rabbit supplemented with 15% canola meal (CM), rabbit supplemented with canola meal and probiotic (CM+PG), rabbit supplemented with 1.5% canola oil (CO), and rabbit supplemented with canola oil and probiotic (CO+PG). The experiment was extended for 8 successive weeks for all groups. We reported that RBCs, Hb, PCV, MCV, MCH, and MCHC in all supplemented groups were non-significantly affected. The serum AST, ALT, ALP, total bilirubin, direct bilirubin, indirect bilirubin, albumin, glucose, creatinine, urea, and HDL levels in all investigated groups were insignificantly varied. A significant reduction was recorded in the serum cholesterol when rabbits supplemented with probiotic. Conversely, it was significantly elevated in CO supplemented group. Whilst, CS, CS+PG, CM, CM+PG, and CO+PG treated groups revealed insignificant change in the cholesterol level. The serum triglyceride level in rabbits supplemented with PG and CS+PG was insignificantly changed. Otherwise, it was significantly increased in the CS, CM, CM+PG, CO, and CO+PG supplemented groups and the highest increase was recorded in rabbits supplemented with canola meal and probiotic. Probiotic mildly improved immunity status of rabbit (increased IgM & nitric oxide), and decreased the blood cholesterol. Canola seed and meal moderately improved rabbits’ immunity (both raised leukocytic count, total protein, and globulin also canola seed increased lysozyme while canola meal increased GSH). Meanwhile, they caused a significant increase in triglyceride only. Moreover, canola oil highly improved the immunity of growing rabbits (increased total protein, globulin, SOD, GSH, lysozyme and decreased MDA). However, it significantly increased lipid profile except HDL. Concerning the growth performance: canola meal and canola oil exhibited the most powerful effect as they increased body weight gain and reduced the feed intake at the same time. Whilst, probiotic and canola seed didn’t exhibit any effect on rabbits’ growth performance.