الفهرس | Only 14 pages are availabe for public view |
Abstract Background: In no other medical situation is a patient at risk for so many liver diseases as during a hematopoietic stem cell transplant (HSCT). Aim : Evaluation of the incidence, causality and severity of drug-induced liver injury (DILI) in HSCT recipients. Patients and methods : All patients post-HSCT presenting to the Nasser Institute were included in the study and those with any other cause of liver injury, were excluded. LFTs monitoring was used for assessment of liver diseases. The type and severity of DILI was determined based on the pattern and degree of LFTs elevation. The use of the Roussel-Uclaf Causality Assessment Method (RUCAM) confirmed the determined causality of DILI. Results : Out of the 132 HSCT patients assessed; 112 (84.8%) were allogenic and 20 (15.2%) were autologous. In allogenic patients, the cumulative incidence of DILI till the end of each of the early, intermediate and late intervals was 27 %, 37.8 % and 46.3 % respectively. There was no significant difference in the incidence of DILI with regards to sex, conditioning regimen category, age, diagnosis category, abnormal chemical and virological parameters pre-transplantation. Causes of DILI were: conditioning regimen (55 %), cyclosporine (40 %) or fluconazole (5%) and the types of injury were; hepatocellular (95%), cholestatic (2.5%) and mixed (2.5%). Injury severity included patients with; (30 %) grade 1, (37.5%) grade 2 and (32.5%) grade 3. One patient developed DILI in autologous patients group. Conclusion: There was no significant difference in the incidence of DILI over the 3 intervals with regards to the different variables. Most cases with DILI post-HSCT were hepatocellular. Conditioning regimen-induced injuries were more severe than CSA-induced. |