الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 269 |  |  |
| | | from | 269 | | |
Abstract
Protozoan diseases remain a major global health problem, especially in tropical and
subtropical countries. Many of these diseases are endemic and recognized as epidemiological
priorities by the World Health Organization (WHO).
< Malaria, leishmaniasis and toxoplasmosis
are common examples to widespread parasitic infections.
Currently, the drugs used in the
treatment of these diseases encountered major limitations, such as resistance, toxicity, cost
extravagance and patient intolerance.
There is therefore an urgent need for suitable drug
offering the following: low-cost manufacturing, innovative structure to overcome drug
resistance and wide therapeutic range.
In addition, It is well known that 1,3-diaryl pyrazole derivatives displayed a wide array of
biological activities including antiprotozoal potential.
Consequently, and as a continuation to
our program, the present study was oriented toward the design and the synthesis of some new
pyrazole derivatives based on the hybridization with heterocyclic scaffolds such as, Nsubstituted
pyrazolines, pyrazolinones and 1,2,4-triazoles. The hybrid molecules were attached
directly or through different spacers (from 1-4 atoms).
<Also, some small hydrophilic and
lipophilic functional groups were inserted at pyrazole-C4 or as a side chains such as oximes, carbonitriles, carboxylic acids, carboxamides, and substituted amides, in addition to various
hydrazones and acrylic acid derivatives in which comparative studies for their antimalarial,
antileishmanial and anti-toxoplasma activities were established.