الفهرس | Only 14 pages are availabe for public view |
Abstract In this part, the phytochemical investigation of the ethyl acetate extract of Dracaena cinnabari Balf. f. resin led to the isolation and identification of 12 compounds: 7-hydroxyflavan, 4’-hydroxy-7,8-methylenedioxyhomoisoflavan, 7,4’-dihydroxy-3’-methoxyhomoisoflavan, 4,4’-dihydroxy-2-methoxydihydrochalcone, 4,4’-dihydroxy-2’-methoxychalcone, 7,4’- dihydroxy-3’-methoxyflavan, 7,3’-dihydroxy-4’-methoxyflavan, 2’,4’- dihydroxychalcone, 7-hydroxy-3’,4’-methylenedioxyhomoisoflavan, sinapaldehyde, dracidione, 7-hydroxyflavanone. Two compounds are new, first time to be isolated from of D. cinnabari resin. Part II: Biological evaluation of Dracaena cinnabari Balf. f. resin. The ethyl acetate extract of D. cinnabari resin showed weak α-glucosidase inhibition activity as compared with acarbose. The isolated compounds exhibited moderate to weak activity. Compound D11was the most active. so, it could serve as a potential candidate for in controlling postprandial hyperglycemia. The ethyl acetate extract of D. cinnabari resin showed moderate COX-II inhibitory activity as compared to the reference drug, celecoxib. The tested compounds showed variable activities. The most active compounds were 4’- hydroxy-7,8-methylenedioxyhomoisoflavan and 4,4’-dihydroxy-2-methoxydihydrochalcone while the least active was 7,4’-dihydroxy-3’-methoxyhomoisoflavan. Treatment with the ethyl acetate extract of D. cinnabari resin at dose of 750 mg/kg showed good renoprotective, antioxidant and anti-inflammatory effects. 7-Hydroxy-3’,4’-methylenedioxyhomoisoflavan exhibited very good renoprotective, antioxidant and anti-inflammatory effects on cisplatin induced acute kidney injury. It significantly decreased cisplatin-elevated nephrotoxicity markers, NF-κB and COX-2 expression. It significantly restored cisplatin depleted GSH and inhibited renal tubular damage. Therefore, compound D2 could be valuable in attenuation of cisplatin-induced nephrotoxicity. |