الفهرس 
Thyroid Gland PhysiologyOnly 14 pages are availabe for public view
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Abstract
D
uring critical illness, changes in circulating hormonal levels are a common phenomenon. These alterations are correlated with the severity and outcome of patients in intensive care unit (ICU). Thyroid hormone plays a key role in the maintenance of the body growth, modulating metabolism and the immune system.
The aim of the study is to assess the relation between thyroid dysfunction and mortality in critically ill patients and to assess the strength of thyroid dysfunction as a predictor of mortality against APACHE II score and CRP, also to assess the additive effect of low FT3 and high APACHE II score as a predictor of mortality.
A total of 40 patients (52 % males, 47.5% females) were enrolled in our study. Our patients were classified according to thyroid function test on 7th day into 2 groups:
group 1: Normal thyroid function group (24 patients).
group 2: Thyroid dysfunction group (16 patients).
The most significant abnormality between the 2 groups was TT3 and FT3.
The patients in thyroid dysfunction group showed significantly higher APACHE II score and CRP but lower GCS. They also needed more mechanical ventilation with longer duration.
There was no significant difference between the 2 study groups as regard cardiovascular complication.
Our study also showed highly significant correlation between thyroid dysfunction and mortality. FT3 appeared to be better predictor of mortality among critically ill patients with AUC 83% and p value <0.001 with sensitivity 99% and specificity 61%. The predictive value of FT3 for mortality increased by the addition of APACHE II score > 25.