الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
 |  | from | 127 |  |  |
| | | from | 127 | | |
Abstract
Non alcoholic fatty liver disease (NAFLD), the hepatic manifestation of metabolic syndrome , represents a spectrum of histopathologic abnormalities ranging from simple steatosis to the more aggressive non alcoholic steatohepatitis (NASH), characterised by steatosis, parenchymal inflammation, hepatocellular ballooning and other evidence of hepatic injury . Patients with NASH are at risk of developing progressive fibrosis; reported in up to 50% of cases over 6 years. Patients with type 2 diabetes mellitus (DM) have an increased risk of developing NAFLD, NASH and hepatic fibrosis/cirrhosis. Furthermore, NAFLD patients with DM have three times the mortality compared to non diabetic NAFLD patients. Apolipoprotein C3 (apoC3) is an exchangeable lipoprotein produced by both the liver and the intestine. In humans, apoC3 expression is also a crucial determinant of plasma triacylglycerol (TAG) levels. In human studies, plasma apoC3 levels are an independent predictor of cardiovascular disease and the progression of atherosclerosis, and in type 1 diabetics the plasma concentration of apoC3 is elevate *100 NAFLD patients and an 83 number of controls were included. All the patients belonged to Egyptian population. We studied the relationship between genetic variants in APOC3 (-455T>C) and (-482C>T) polymorphisms and the risk of non alcoholic fatty liver disease. All participants were subjected to an estimation of their body mass index (BMI) in addition to liver functions and lipid profile. Polymerase chain reaction with sequence-specific primers (SSP-PCR) was performed to detect the of APOC3 rs2854116 and rs2854117 polymorphic genotypes. **The polymorphism T-455C but not the C-482T in APOC3 gene was associated with NAFLD in Egyptian obese subjects. However, it did not affect their hematologic, liver and lipid profile parameters. Comparing cases of fatty liver carrying the rare allele of C-482T and T-455C of APOC3 gene vs. others found that the distribution of BMI values, hematologic, liver functions, and lipid parameters between showed that all parameters were nearly having a similar distribution denoting that these polymorphisms were not affecting the clinical characteristics of these cases.