الفهرس 
Synthesis and Reactions of Malononitrile Derivatives
Synthesis from indole-2,3-diketonesOnly 14 pages are availabe for public view
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Abstract
In this study 3-amino-1-(2-chlorophenyl)-1H-benzo[f]chromene-2-carbonitrile has been utilized to design and synthesize a series of benzo[f]chromene-based heterocycles for biological evaluation as antimicrobial and anticancer agents.
Benzo[f]chromene-based heterocycles result from chemical transformation of enaminocarbonitrile, ethyl formimidate and cyanomethyl functionalities using various carbon electrophiles and nitrogen nucleophiles.
The newly synthesized compounds were evaluated for their in vitro antitumor effect against two human tumor cell lines namely; heptacelluar carcinoma (HePG2), and breast cancer (MCF-7) and the results revealed that compounds 3, 9, 25, 38 exhibited very strong cytotoxic activity for both cell lines.
Key words: enaminonitriles, 1H-benzo[f]chromenes, benzo[5,6]
chromeno[2,3-d]pyrimidines,benzo[5,6]chromeno[3,2-e] [1,2,4] triazolo [1,5-c]pyrimidines.