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العنوان
Effect of Using Leukocyte Filter on Ventilatory Functions among Transfusion Dependant Thalassemics /
المؤلف
Abd El Gawad,Alia Osama Ali .
هيئة الاعداد
باحث / Alia Osama Ali Abd El Gawad
مشرف / Ahmed El Saiid Hamed
مشرف / Terez Boshra Kamel
مشرف / Iman Ahmed Ragab
تاريخ النشر
2013
عدد الصفحات
192P.;
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
طب الأطفال ، الفترة المحيطة بالولادة وصحة الطفل
تاريخ الإجازة
1/1/2013
مكان الإجازة
جامعة عين شمس - كلية الطب - طب أطفال
الفهرس
Only 14 pages are availabe for public view

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from 192

Abstract

Pulmonary dysfunction is one of the least understood complications of thalassemia major, although it is not uncommon, having been reported in up to 80% of patients with the disease.
The aim of this study is to assess the ventilatory functions (FVC, FEV1, and FEV1/FVC) among transfusion dependant thalassemics before and 6 months after the application of the Leukocyte filter (a device which reduces the number of leukocytes in blood) within each transfusion.
This study included 30 patients with transfusion dependent Thalassemia Major recruited from the regular attendants of the Hematology Clinic, Children’s Hospital, Ain Shams University
They were subdivided into 2 groups according to their use of Leukocyte filter.  group I: included 15 Thalassemics who used the Leuckocyte filter before each blood transfusion for 6 months. Their ages ranged between (7 -17) years with a mean of (12.4) years. They were 5 (33.3%) males and 10 (66.6%) females.group II (Control Group): included 15 Thalassemics who did not apply the Leuckocyte filter. Their ages ranged between (8-17) years with a mean of (12.27%) years. They were 7 (46.7%) males and 8(53.3%) females.
All Patients were subjected to the following:
I. Careful history taking:
Lying stress on: age, sex, frequency of transfusion, any symptoms related to any chest disease and history of splenectomy.
II. Physical examination:
With special emphasis on: Anthropometric measurements (weight and height) and chest examination.
III. Laboratory Investigations:
Serum Feritin
IV. Chest X-Ray
Was done for each patient before the use of the Leuckocyte filter and after its use for 6 months V. Pulmonary Function Tests (PFTs) Spirometric studies including: - FEV1%: Forced expiratory volume in the 1st second. - FVC%: Forced vital capacity.
- FEV1/FVC%: Forced expiratory volume in 1st second percent This study revealed the following results:  Significant higher number of normal chest x-ray after compared to before use of Leucocyte filter in group 1.  Statistical significance between group 1 between the chest x-ray findings before and after using the Leukocyte filter(p value < 0.05) while there was no statistical difference between group 2 between the 1st and 2nd chest x-ray findings (p value >0.05).
 No statistical significance between the Serum Ferritin level in the two studied group (p value >0.05).
 Statistical increase in the percent age of patients with normal pulmonary functions after using the Leucocyte filter (p< 0.05), while there was no statistical difference between group 2 patients between the 1st and 2nd measurement of the pulmonary functions (p >0.05). No statistical significance between the 1st and 2nd measurement of the PFTs of the two groups with a p value of all items >0.05.
 Statistical significance between the 1st and 2nd measurements of PFT in group 1 with a p value for FEV1, FVC and FEV1% FVC <0.05.
 There was no statistical significance between the 1st and 2nd measurements of PFT in group 2 with a p value for FEV1, FVC and FEV1% FVC >0.05
 There was no statistical difference between the splenectomized and non-splenectomized patients regarding the Pulmonary Function tests before and after applying the filter.
 There was no correlation between Serum Ferritin and PFTs of both groups (p > 0.05).
Finally from the present study we can conclude that that removing most of the leukocytes from the blood during transfusions prevents bronchoconstriction and improve FEV1, FVC, FEV1/FVC
Pulmonary function abnormalities consults 53.3% of studied -Thalassemia patients.Improvement of pulmonary function abnormalities in beta Thalassemis major patients on regular transfusion after applying the bedside leukocyte filter and worsening of pulmonary functions in patients using non-leukocyte filtered blood.