الفهرس 
Background and Literature ReviewOnly 14 pages are availabe for public view
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Abstract
Surface functionslisation of polysulfone (PSU) substrates was accomplished by grafting hydrophilic monomer, methacrylic acid (MAA), using the air plasma-induced graft polymerization (APIGP) approach. Air plasma was used to create hydroxyl groups on the surface and subsequent graft polymerisation of MAA monomer was initiated by Ce(IV) to introduce carboxyl groups. The carboxyl groups were then reacted with (DADPA) to introduce amino groups. Finally, β.CD was attached covalently on to the PSU film surface. Air plasma treatment of the PSU film was carried out in a low temperature low pressure plasma machine. After the plasma treatment, an aqueous solution containing a mixture of MAA, H2SO4 and ammonium cerium (IV) nitrate was prepared, mixed, and refluxed at definite temperature and time in an inert nitrogen atmosphere. The plasma-treated film was added to the reaction mixture and the reaction was continued at definite temperature and time in the inert nitrogen atmosphere. The resulting material is notated as PSU-PMAA film. The PSU-PMAA was thoroughly rinsed with an aqueous solution of NaOH for specific time to remove the unreacted monomer and then the film was rinsed in distilled water (DI) overnight. The neutralised PSU-PMAA film was immersed into an aqueous solution of MES buffer containing (MES, NHS and EDAC) at definite temperature and time. The film was then immersed in an aqueous solution of DADPA and reacted at definite temperature and time. The PSU–PMAA–DADPA film was rinsed with DI water thoroughly. The resulted PSU-PMAA-DADPA films was finally functionalised with β.CD as a potential vehicle for the design of drug delivery devices via complexation by adding varying amounts of β.CD in DI water in an Erlenmeyer flask with a rubber stopper, and was shaken in a water bath at definite temperature and time. PSU-PMAA-DADPA film was then added and the reaction was maintained at specific time and temperature. The temperature of the reaction was then increased. At the end of the reaction, the film was removed and was washed with DI water. The resulting material is referred to as PSU–PMAA–DADPA–β.CD film. The characterisation was accomplished on PSU-PMAA-DADPA films by measureuing the surface tension and contact angle to evaluate the hydrophilic properties and atomic force microscopy (AFM) to analyse morphological structures. Also, the creation of functional groups was determined by ATR-FTIR while grafting yield was estimated by weighing of films both before and after grafting. We managed to obtain an improvement in hydrophilicity which found to be permanent even after 40 days. We have also charechterised the resulted PSU–PMAA–DADPA–β.CD film by using ATR-FTIR to confirm the functional groups that created.The functionalisation of PSU-PMAA-DADPA film with β.CD was verified by UV absorbance by immersing PSU–PMAA–DADPA–β.CD film in alkaline solution of phenolphthalein (PHP), which formed inclusion complexes with the attached β.CD. A reduction in absorbance of the PHP solution was observed. The resulting materials are promising candidates for use as drug delivery substrates.