الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
The thesis comprises four main parts Part I This part contains a general introduction about the chemical names, structures, physical properties, pharmacological actions and uses of the studied drugs.
It also contains literature reviews for the pharmacopoeial and other reported methods of analysis for the selected drugs in pharmaceutical dosage forms as well as in biological fluids.
<Part I It deals with the development, validation and application of several simple and direct spectrophotometric and chromatographic methods for the analysis of ketorolac tromethamine binary and ternary mixtures.
This part comprises five chapters.
Chapter 1: This chapter describes different simple and rapid spectrophotometric methods for the determination of a binary mixture containing ketorolac tromethamine (KTC) and phenylephrine hydrochloride (PHE) and their ternary mixture with chlorpheniramine maleate (CPM).
The proposed methods involve (a) using zero-order spectra, (b) first derivative spectra, (c) treatment of the absorbance ratio spectra using derivative or difference functions, (d) treatment of zero-order spectra using delta absorbance method and (e) treatment of derivative spectra using discrete Fourier function.
In the binary mixture, KTC is assayed using zero-order (D0) spectra, first derivative (D1) spectra and delta Absorbance (ΔA) method with no interference from PHE, while PHE needed some spectroscopic treatments for its analysis due to the spectral overlap of KTC with the maximum wavelength (λmax) of PHE at 273nm. Such treatments involve first derivative (D1) spectra absorbance ratio difference (R.D), second derivative of absorbance ratio (D2R), discrete Fourier function on the second derivative (FFD2) spectra and delta Absorbance (ΔA) method. In the ternary mixture, KTC is assayed using zero-order (D0) spectra and first derivative (D1) spectra with no interference from both PHE and CPM, while absorbance ratio difference (R.D), first derivative of absorbance ratio (D1R) and discrete Fourier function on the second derivative (FFD2) spectra are used to assay both PHE and CPM to resolve the mixture and to overcome the extensive spectral overlap. Linear regression lines were obtained over the concentration ranges 1-18 and 6-48 μg.mL−1 for KTC and PHE (binary mixture), respectively and 1-18, 2-9 and 2-9 μg.mL−1 for KTC, PHE and CPM (ternary mixture), respectively with correlation coefficients higher than 0.999. The methods were successfully applied to the analysis of the three drugs in their synthetic mixtures and in their dosage forms.