الفهرس 
Mycobacterium TuberculosisOnly 14 pages are availabe for public view
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Abstract
The emergence of drug-resistant M. tuberculosis is a
global concern. Rapid, simple drug susceptibility tests that
are applicable in developing countries would allow earlier
treatment of patients with MDR infections.
The aim of this study was to evaluate the Colour Test
TLA techniques, as a phenotypic method, for detecting
drug resistance among M. tuberculosis strains.
Fifty M. tuberculosis clinical strains were tested by
TLA. The results of this technique were compared to the
gold standard proportional method. Twenty-four (48%)
strains out of the 50 were diagnosed as MDR-TB by the
Colour test, while by the proportional method 27 (54%)
strains were MDR-TB and 2 (4%) were XDR-TB out of the
50 tested strains.
The sensitivity of the TLA, for RMP and INH
susceptibility testing was 100% for both of them. While for
CIP, the sensitivity was 96.7%. The specificity was 90.3%,
90.3% and 90% for RMP, INH and CIP respectively.
The agreement of the Colour test for each of the 3
drugs was 87.6%. PPV was 90% for the 3 drugs, and the
NPV was 100%, 100% and 96.6% for RMP, INH and CIP
respectively.