الفهرس 
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PATHOLOGY OF PULMONARY TUMORSOnly 14 pages are availabe for public view
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Abstract
MRI is a clinically powerful diagnostic technique that is well recognized for its ability to depict and characterize benign and malignant disease. MRI uses many types of sequences that investigate a different tissue characteristic, providing radiologists and clinicians with much information about the healthy and diseased structures.
Diffusion-weighted imaging has been used for assessment for tumors. Results of studies comparing apparent diffusion coefficients (ADCs) and histopathological finding have strongly suggested that greater cellularity is associated with more restricted diffusion.
It was found that diffusion weighted imaging (DWI) can be used for reliable differentiation between compartments of viable tumor and of tumor necrosis based on significant differences in the ADC, and seem to be a potential, non-invasive diagnostic tool for monitoring early tumor response and also for tissue characterization in vivo.
This prospective study was carried out at Radiology department, in , faculty of medicine Assuit university in the period from February 2016 to February 2017.
The aim of this study of to evaluate the role of MRI especially diffusion-weighted MRI in characterization of pulmonary masses and its value in the differentiation between benign and malignant ones.
In this study thirty-two patients ware included (23 males and 9 females) having pulmonary mass in their CT chest with mean age (52.78± 15.03 years)
All patient included in the study were subjected to through clinical history and physical examination, routinelaboratory investigation, CTchest, MRI, bronchoscopy and/or CT guided biopsy for pathological examination, except in some cases as pneumonia in which we depend on clinical evaluation.
The results of this study revealed the following:
-malignant pulmonary masses in 24pateint and the pathological types were; adenaocarcinoma (3cases), squamous cell carcinoma (3cases),large cell carcinoma(3 cases),small cell carcinoma (3cases), lymphoma (2 cases),CLL (1 case),round cell tumor(1 case), epitheloid cell neoplasm (1 case),metastatic tumor (7cases). Benign pulmonary masses in 8 patients that were; pneumonia (3cases), lung abscess (1case), tuberculosis (1case) , Fungal mass(2cases), hydatid disease (1case) .
-it was noticed that; the mean ADC value higher in the different pathological types of benign group (1.78±0.74 × 10-3 mm2/s ), than that found in the different pathological types of the malignant group (1.05± 0.25× 10-3 mm2/s) with statistically significant difference (p<0.000).
-in case of malignant pulmonary masses, it was found that the cut off value of the ADC between benign and malignant pulmonary masses using receiver operating curve (ROC) is1.25 × 10-3 mm2/s, i.e the ADC value for any pulmonary mass> 1.25 × 10-3 mm2/s could exclude the possibility of malignancy and a value below this threshold could raise the possibility of malignancy with 91.7% sensitivity, 75% specificity.