الفهرس 
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Abstract
Summary
Children with chronic kidney disease (CKD) have
multiple risk factors for Anemia such as primary
Erythropoietin deficiency, blood loss, decreased red blood
cell (RBC) survival, Bone Marrow (BM) suppression, iron
deficiency, inflammation and infection, malnutrition,
hyperparathyroidism, vitamin B12 and folate deficiency,
aluminum toxicity and carnitine deficiency.
Iron deficiency and iron deficiency anemia are the
most common iron disorders throughout the world.
In our follow up clinical study, 45 chronic kidney
disease (CKD) pediatric patients who are iron deficient
within the pediatric nephrology conservative clinic,
children’s hospital, Ain Shams University, were subjected
to pravotin (lactoferrin) intervention with monitoring of
blood Hb and RBC volume before intervention and after 6
months with regular monthly check of both…and
monitoring of Iron profile including serum iron, serum
ferritin, total iron binding capacity (TIBC) before and after
6 months of treatment.
The current study found that blood Hb and RBC
volume significantly increased beginning from first month
after oral lactoferrin therapy, serum iron significantly
increased six months after intervention, serum ferritin
significantly increased six months after intervention, and
serum TIBC significantly decreased after intervention.
Summary
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The current study had also shown no significant
difference between males and females regarding lab
changes 6 months after intervention, lab improvements
were significantly lowest among cases with stage IV,
followed by stage III and highest among cases with stage
II.
It had also shown all anemia clinical manifestations
decreased 6 months after treatment; the differences were
significant only in easy fatigability, constipation and
gastrointestinal upset were most frequent side effects