الفهرس 
Fetal Membranes and Preterm Premature Rupture of MembranesOnly 14 pages are availabe for public view
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Abstract
Background: The purpose of this study was to validate a non-invasive fetal lung maturity test by counting lamellar bodies from a vaginal pool among women with preterm premature rupture of membranes. Aim of the Study: This study is designed to assess the efficacy of the amniotic fluid lamellar body counting from vaginal pool in predicting fetal lung maturity in women with preterm premature rupture of membranes. Patients and Methods: This study was conducted as a prospective cohort study (accuracy of a diagnostic test).at Ain Shams University Maternity Hospital from October 2015 till August 2016. Results: The study showed that using 38.131/ml as a cut-off point for LBC it is a good predictor for fetal lung maturity with sensitivity 96% and specificity 97.22%. Conclusion: Lamellar body count (LBC) is an effective, safe, easy, cost-effective method to detect fetal lung maturity (FLM). It does not need a highly equipped laboratory or specially trained personnel, it just need the conventional blood count analyzer. Measurement of LBC is now replacing the conventional Lecithin/Sphyngomyelin L/S ratio. LBC cut-off value of 38.131/ml can be used safely to decide fetal lung maturity with sensitivity 96% and specificity 97.22%. Recommendations: Lamellar body count (LBC) has taken its place in many laboratories and feto-maternal centers worldwide to confirm fetal lung maturity (FLM) in high and low risk cases. The clinical outcome and the cost-effectiveness of LBC should be prospectively evaluated. Further studies are needed to compare between lamellar bodies count and other tests used to detect fetal lung maturity as lecithin/sphingomyelin ratio and phosphatidyl glycerol.
Key words: Lamellar bodies count, fetal lung maturity, PPROM