الفهرس 
Chronic Kidney Disease in Children
EtiologyOnly 14 pages are availabe for public view
 |  | from | 130 |  |  |
| | | from | 130 | | |
Abstract
This study was carried out in Pediatric Conservative
Nephrology clinic, Children’s Hospital, Ain Shams
University in the period from January to September 2015.
The study was conducted on 45 children, 35 patients
with chronic kidney disease following up at the pediatric
conservative nephrology clinic, Children’s Hospital, Ain
Shams University, and 10 age & sex matched healthy
children serving as control group.
group I (cases): included 35 patients with chronic
kidney disease with glomerular filtration rate (GFR) <
60 ml/min/1.73m² & duration of the disease not less than
6 months. (29 males & 6 females), their ages ranged
from 1 year up to 14 years with mean age 5.1 ± 3.3
years.
group II (controls): included 10 apparently healthy age
& sex matched children (7 males & 3 females). their
ages ranged from 2 years to 10 years with mean age 5.3
± 3.1 years.
All patients were subjected to detailed history taking,
laying stress on medication history, thorough physical
examination with special emphasis on: blood pressure
measurement, weight, height & body mass index (BMI).Lab investigations included: complete blood count (cbc),
serum creatinine & corrected creatinine clearance. Serum
and urinary angiotensinogen were measured for each
patient enrolled in the study as well as the control group
using Human Angiotensinogen ELISA kits.
Results of our study revealed that:
Urinary angiotensinogen excretion was significantly
higher in children with CKD compared to controls.
Also urinary angiotensinogen was significantly
associated with decreased kidney functions (inverse
relationship with GFR).
Serum angiotensinogen was also elevated in CKD
patients compared to controls but the levels of urinary
angiotensinogen were much higher.
In conclusion, urinary angiotensinogen can be possible
marker that can indicate renin angiotensin system activity in
CKD Children.
Recommendations: we recommend further studies on
Urinary & Serum Angiotensinogen in children with CKD
especially those on anti-hypertensive TTT (ACEI & ARBS)
for further understanding of their possible role in
hypertension & progression of CKD.