الفهرس 
? Helicobacter Pylori InfectionOnly 14 pages are availabe for public view
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Abstract
Helicobacter pylori is a helix-shaped Gram negative
bacterium with 4-6 flagella. It produces catalase, and
urease, oxidase.
Helicobacter pylori infection is considered one of the
most common chronic bacterial infections worldwide
affecting large number of the general population in both
developing and developed countries.
Colonization with H.pylori is not actually a disease
but remian the relative risk of developing multiple clinical
disorders of the upper gastrointestinal tract like (peptic
ulcers ,chronic gastritis ,gastric adenocarcinoma & MALT
lymphoma) and, possibly, may cause extragastric diseases
like (Atherosclerotic heart disease, iron deficiency anemia,
Immune thrombocytopenic purpura and others).
The most common route of transmission of H.pylori
is faeco-oral transmission. there are multiple methods of
available to detect H.pylori infection including invasive
methods based on gastric biopsies and noninvasive
methods like serology, urea breath tests (UBTs), and stool
antigen tests.
Insulin resistance which is a pathologic state in which
normal insulin concentrations produce a subnormal
response in the peripheral tissues. This insulin resistance
can progress to full Type 2 diabetes mellitus (T2DM Insulin resistance results from multiple inherited and
acquired causes. Hereditary causes like mutations of insulin
receptor, glucose transporter, and signaling proteins,
Acquired causes like physical inactivity, fatty diet and the
aging process. Combinations of causes are common.
There are several measures can be used to determine
insulin resistance but The HOMA-IR model has proved to
be an excellent clinical and epidemiological tool for the
assessment of IR.
The relationship between H.pylori infection and
insulin resistance have shown in some studies but the sure
association remain controversial. So, The aim of the present
study is to search the relation between Helicobacter pylori
infection and Insulin Resistance.
The current study was conducted upon 80 patients
complaining of dyspepsia recruited from gastroenterology
and Hepatology unit, department of internal medicine, Ain
Shams University hospital in the period from March 2016
to July 2016. Subjects were subdivided into two group;
-a case group (A) including 40 patients with H.pylori
positive diagnosed by histopathology.
-a control group (B) including 40 patients with
H.pylori negative diagnosed by histopathology.In this study ,there is no statistical significant
difference between group A and B as regards the HOMAIR where the p value was 0.5 .
In conclusion there is no association between
Helicobacter pylori infection and Insulin resistance. So,
eradication of H.pylori infection not lead to decrease of
insulin resistant .