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Abstract
Effect of fortified bread with some plant seeds on diabetic rats
By
Hanan Amin Abdel-Mogoud Hessien Ph.D. Thesis (2012)
Nutrition and Food Science Department, Faculty of Home Economics- Helwan University
The present work was conducted to manufacture fortified bread with turmeric and some plant seeds suitable for diabetes and study the effect of fortified tunneric bread with fenugreek, flaxseed and pumpkin seeds on glucose, lipids profile, kidney functions and liver enzymes in serum of diabetic rats. Two main experimental groups were established: Group 1 (n = 6 rats) used as a negative control group fed on diet containing 300 g unfortified bread. Group 2(60 rats): were injected with alloxan (150 mglkg body weight) to induce hyperglycemia and fed on basal diet, then this group was divided into ten subgroups (6 rats each). Subgroup (1) fed on diet containing 300 g unfortified bread (as a positive control group). Subgroups (2) fed on diet containing 300 g fortified bread with (1.5%) turmeric. Subgroups from (3 ¬10) fed on diets containing 300 g fortified turmeric bread with 50/0 and 15% (fenugreek, flaxseed, pumpkin seeds and combination of all seeds), respectively. Injected rats with alloxan caused significant decrease in food intake, BWG %, HDL-c, calcium and phosphorus while the mean values of serum glucose, cholesterol, triglycerides, LDL-c, VLDL-c,uric acid, urea nitrogen, creatinine, AST, AL T, and ALP, heart, kidney and liver weight / body weight % increased significantly in the positive control group, as compared to the negative control group. Treated diabetic rats with the fortified bread with turmeric (1.5%) and fortified turmeric bread with fenugreek, flaxseed, pumpkin seeds and combination of all these seeds improved all parameters, especially the group