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العنوان
Behaviour of some B-unsaturated keto acid derivatives towards carbon and nitrogen nucleophiles /
المؤلف
Morsy, Mohammed Abd El-hammed.
هيئة الاعداد
باحث / محمد عبد الحميد مرسي
مناقش / ا.د/ ماهر عبد العزيز الحشاش
مناقش / ا.د/عبد المنعم محمد فرج عيسي
مناقش / ا.د/ عبد الفتاح محسن بدوي
الموضوع
Carbon. Nitrogen. Ammonium carbonate.
تاريخ النشر
2010.
عدد الصفحات
211 p. :
اللغة
الإنجليزية
الدرجة
الدكتوراه
التخصص
Organic Chemistry
الناشر
تاريخ الإجازة
1/1/2010
مكان الإجازة
جامعة قناة السويس - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Due to their high electrophlicity of bB-aroyl acrylic react readily with nuclophiles, including active methylene compounds affording either cyclic or normal Michael addition products.The present work is devoted to study the interaction of 4-(4-acetoaminophenyl)-4-oxo-but-2-enoic acid (1) with carbon nucleophilic cyclohexanone,cyclopentanon,ethyl cyanoacetate and ethyl acetoacetate in ethanol in the presence of NaOH (50%) Michael addition to afforded compounds (2a-e).On the other hand, when compound 1 was allowed to react with cyclohexanone in the presence of ammonium acetal to give compound (3).Interaction of the acid 1 with highly and moderately reactive hydrocarbons e.g p-xylene and acetanilide in the presence of anhydrous aluminum chloride under friedel-crafts reaction condition afforded (4a-b).Thus , when acid 1 was allowed to react with benzyl amine in dry benzene yielded(5)