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Abstract
HCV infection and diabetes are two common disorders with a high impact on health worldwide.
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The hepatitis viruses, particularly HCV, can affect not only the liver but also several tissues outside the liver, resulting in a wide spectrum of extrahepatic manifestations and morbid conditions to which diabetes mellitus has been included.
During the last decade, it was hypothesized that diabetes could be one of more extrahepatic condition attributable to HCV infection.
TNF-a may be the link between HCV infection and diabetes, suggesting an additional mechanism of diabetes with important implications for prognosis and therapy To review the relationship between HCV infection and the development of DM and the effect of HCV on diabetic patients .