الفهرس 
INTRODUCTION
Genes related to inflammationOnly 14 pages are availabe for public view
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Abstract
The metabolic syndrome is a cluster of risk factors, which is associated with substantial risk of T2D and CVD. It has been intensely investigated by many organizations which gave various definitions for MetS, each of which resembles a group of criteria for its diagnosis. Although these definitions actually differ somewhat, they all agreed that abdominal obesity, hypertension, dyslipidemia and hyperglycemia are core components for clinical diagnosis. Many epidemiological studies have reported the prevalence of MetS in various populations, among different age and sex groups. The prevalence of the MetS is generally increasing with age, higher in middle aged men than in women and varies with ethnicity. Prevalence data for the MetS in different countries clearly show that the syndrome represents a large and progressive worldwide problem. The etiology of MetS is complex, being determined by interplay of environmental and genetic factors. However, heritability is a substantial contributor to the MetS. Many studies have considered the close relation between the insulin resistance and visceral obesity as a major two risk factors in the pathogenesis of MetS. In addition to insulin resistance and obesity, other risk factors including inflammatory factors, adipocytokines, cortisol, oxidative stress, vascular factors and lifestyle factors are operative in this process. Also, abnormal adipose tissue metabolism seems to play a central role in the events leading to the development of a cluster of metabolic anomalies.