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العنوان
Lactoferrin with Ferrous Gluconate versus Ferrous Gluconate for Treatment of Iron Deficiency Anaemia during Pregnancy \
المؤلف
Khattab, Nahla Fathy Abdel-samea El-sabai.
هيئة الاعداد
باحث / نهله فتحى عبد السميع السباعى خطاب
مشرف / وليد هتلر
مشرف / عمرو سعد
مناقش / وليد هتلر
تاريخ النشر
2024.
عدد الصفحات
103 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
أمراض النساء والتوليد
تاريخ الإجازة
1/1/2023
مكان الإجازة
جامعة عين شمس - كلية الطب - أمراض التوليد والنساء
الفهرس
Only 14 pages are availabe for public view

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Abstract

I
ron deficiency is the most common single-nutrient deficiency worldwide. According to the US Centers for Disease Control and Prevention (CDC) recommendations, the diagnosis of anemia during pregnancy must be based on hemoglobin (Hb) values lower than 11 mg/dl during the first and the third trimester or lower than 10.5 mg/dl during the second trimester.
Ferrous gluconate that has to be administered to patients with iron deficiency anemia in large quantities due to the poor bioavailability of inorganic iron. Moreover, oral administration of ferrous gluconate causes many side effects, including gastrointestinal discomfort, nausea, vomiting, diarrhea and constipation.
Lactoferrin is a multifunctional iron-binding protein possessing anti-inflammatory and anti-microbial effects. The major advantages of lactoferrin compared with traditional iron supplement ferrous gluconate are well gastrointestinal tolerance and fewer side effects caused by the intake of high-dose iron.
Aim of the Study:
The study aims to compare between lactoferrin with ferrous gluconate versus ferrous gluconate alone in treatment of iron deficiency anemia during pregnancy.
The main results of the study revealed that:
1. There is no significant difference between the groups in terms of age or gestational age.
2. group B had a significant increase in hemoglobin, hematocrit and serum ferritin level as compared to group A.
3. group A had significantly more nausea than group B (p = 0.013), while there was no significant difference between the groups in terms of constipation or non-compliance (p > 0.05).