الفهرس 
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Abstract
Burns cause inflammation, tissue destruction, infection, death, and severe disability; they are among the worst injuries that may happen. Burns may be categorized as superficial, half thickness, or complete thickness based on the depth of the damage. Superficial burns, often called first-degree burns, only impact the outside layer of skin. A partial thickness burn, sometimes called a second-degree burn, occurs when the lesion goes through the dermal layer. Infection and a drastic reduction in blood circulation are two of the potential consequences of burns.
Traditional medicine practitioners have long relied on green coffee bean powder for wound healing. Many local health authorities have confirmed that this powder, when sprinkled over a lesion, does not promote infection. Coffee contains phenolic compounds and chlorogenic acids as well as alkaloids, ditropenoid alcohols, and caffeine, among other chemical components (camentol and kahhol). Studies have shown that chlorogenic acids hasten the recovery time for burns and other skin injuries. Green coffee has more chlorogenic acids than roasted coffee, and the levels of these acids are varied in the two types of coffee.
The purpose of the study:
Examining how green coffee speeds the recovery of albino rats from thermal burns inflicted to the deepest second degree of skin is the primary goal of this study. Examining how green coffee speeds the recovery of albino rats from thermal burns inflicted to the deepest second degree of skin is the primary goal of this study.
Materials and methods:
In this study: 36 adult male white rats were divided into 3 groups of 12 rats each:
The first group (control group): healthy rats without burn injuries.
The second group (burned): rats with second-degree thermal burn.
The third group (burned and treated with green coffee).
Skin tissues were taken on the first, fourteenth, and twenty-first days after the skin burn occurred, and then they were fixed and prepared for study by light microscopy, immunohistochemical study, and standard study.
Results:
The results of the current study revealed the following:
In slides stained with hematoxylin and eosin: skin samples from the second group showed the presence of scars, loss of skin layers and hair follicles, and an inability to heal the wound at the end of the experiment, while skin samples from the third group showed a noticeable improvement in burn healing.
The connective tissue in the dermal and epidermal layers of the second group showed a statistically significant reduction in collagen fibers in slides stained with Masson trichomes, while the third group showed a statistically significant progressive rise in collagen fibers.
In the treated group, vascular endothelial growth factor was shown to occupy a much larger area than in the second group, according to the immunohistochemistry analysis.
A statistically significant increase in the number of positive cells was seen in the treated group compared to the second group in the immunohistochemistry analysis against nuclear proliferating cell antigen.
Ultimately, the research presented earlier suggests that second-degree thermal burns may impair skin tissue structure. The damage caused by the burn may be mediated by inflammation and oxidative stress. The antioxidant, anti-inflammatory, and revitalizing qualities of green coffee extract when applied topically also contribute to its positive benefits.