الفهرس 
Vitiligo
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Abstract
Background: Vitiligo is a skin disorder characterized by loss of melanocytes from the epidermis. C-X-C motif chemokine ligand 10 (CXCL10), is linked to the Th1 pattern and have been suggested as one of the most relevant chemokine axes that promote T cell migration in different autoimmune and inflammatory process. These were suggested to promote melanocyte-specific cytotoxic T lymphocyte (CTLs) to infiltrate into the basal layer of the epidermis to attack melanocytes, resulting in the deficiency of melanin. Objective: The aim of this study was to assess immunohistochemical (IHC) expression of CXCL 10 in skin lesions of patients with vitiligo to explore its possible role in the pathogenesis of the disease. Subjects and methods: We examined biopsies from the lesional skin of 20 vitiligo patients for IHC expression of CXCL 10: 10 patients presented with stable non-segmental vitiligo (group A), 10 patients presented with active non-segmental vitiligo (group B), and 10 apparently healthy volunteers were examined as controls (group C). Results: Nine patients in group A had mild IHC expression of CXCL 10 (+1) and one patient had moderate expression (+2). In group B, 8 patients had strong expression of CXCL 10 (+3) and the remaining patients had moderate expression (+2). However, there was no expression of CXCL 10 in all skin specimens in the control group. Conclusion: CXCL10 IHC expression was increased in vitiligo lesions indicating a possible role in the pathogenesis of disease. The expression was significantly increased in active compared to stable vitiligo. Keywords: Vitiligo, CXCL10.