الفهرس 
Aim of the workOnly 14 pages are availabe for public view
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Abstract
Silicone (polydimethylsiloxane) is a polymeric compound manufactured with different properties, used to create varieties of medical devices. By increasing the amount of cross-linking, silicone can be changed from a liquid to a more viscous gel status. Silicone Breast implants have been used for reconstructive & aesthetic surgeries for over 60 years.
Several reports suggest that silicone products are associated with different complications that may involve either an immunological reaction to silicone (foreign body reaction) or development of a systemic autoimmune disease.
Presently, it is uncertain which complications have a cause-andeffect relationship and which represent coincidental findings. There is further confusion in distinguishing between nonspecific reactions and reactions that have an immunological basis.
because of these increasing allegations of diseases from silicone, Breast implants are among the most highly scrutinized devices approved by the US Food and Drug Administration (FDA). Few medical devices have undergone the degree of scrutiny and speculation that silicone breast implants have. At the present state, there is overwhelming evidence to support the safety of silicone breast implants. Recent published studies in addition to our study shows that statistically significant increase in levels of Lymphocytes (certain immunophenotypes), ESR and CRP postoperatively compared to preoperative levels because of human body reactions to these silicone breast implants without association of clinical symptoms and manifestations that could be observed. In our study, according to C-reactive protein, findings indicate systemic inflammation were present up to 3-month post-operative. This elevation was not a circumstantial or random finding, as associations that were absent before operation, suggesting postoperative pro-inflammatory response. This leading to a relatively nonspecific correlation was observed with silicone implant prosthesis after 6-months assessment when perioperative trauma could no longer be involved. Acute phase reaction could signal immunological reaction of silicone and long-term studies monitoring is highly recommended. CD3, CD4 &CD8 were found to have significantly increased initially after inserting silicone mammary implant, these data demonstrated that T cells predominated over B cells. These results suggest that the silicone present in breast implants might induce a strong T cell immune response. Our findings could shed some light to understand the association of silicone breast implants and some cases of anaplastic large cell lymphomas. As positive CD30, in BIA-ALCL is a first step for diagnosis. However, it is nonspecific and can be expressed in other large B-cell lymphomas. So, If CD30 positive further additional markers such as T-cell and B-cell markers are needed. So, the significant rise of CD3,CD4 & CD8 finding could be used after further detailed prolonged studies to monitor and corelate association between lymphocytic and histiocytic immunophenotypes and clinicopathologic features For patients with complicated mammary silicone implants (capsular contracture, breast implant illness).