الفهرس 
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Abstract
Details of the studies on the synthesis, spectral characterization, and analytical applications of some new transition metal complexes of the Schiff bases derived from 2-hydroxy-1-napthaldehyde are presented in this thesis Schiff-bases are very important material for inorganic chemists as these are widely used in medicinal inorganic chemistry due to their diverse biological, pharmacological, antitumor activities. Recently, there has been tremendous interest in studies related to the interaction of transition metal ions with nucleic acid because of their relevance in the development of new reagents for biotechnology and medicine. The thesis is divided to three chapters and pronounced as follows:
Chapter 1: Introduction and Literature Review
In chapter I, involves a general introduction to Schiff bases and their transition metal complexes. Brief discussion about the applications of Schiff bases and their metal complexes in various field, importance of Schiff base transition metal complexes, antioxidants and its biological importance are included in this chapter, preparation of Schiff base and its complexes derived from previous studies of some research projects.
Chapter 2: Experimental Work
This part is broadly giving the details of the preparation and spectral characterization of monodentate Schiff base ligands {L1: (Z)-1-(4-((4-(dimethylamino)benzylidene)amino)phenyl)ethan-1-one and L2: (Z)-1-(4-((3,4-dimethoxybenzylidene)amino)phenyl)ethan-1-one and their complexes with Fe(III), Ni(II) and Cu(II) ions. Also, biological efficiency of the reported compounds was investigated through studying their ability to interact with Ct-DNA and their antioxidant abilities.
Chapter 3: Results and discussion
This chapter deals with characterization of the reported compounds by using elemental microanalysis, conductometric measurements, magnetic susceptibility, and spectroscopic studies (UV-Vis, mass spectral analysis, FT-IR, TGA and EPR. Furthermore, the DNA binding study was performed on calf-thymus DNA by absorbance, fluorescence, and viscosity measurement. Notably, compared with those of so-called DNA intercalative complexes the complex can bind to DNA via an intercalation mode in the order of Cu-Complex (6) Cu-Complex (3) Ni-Complex (5) Ni-Complex (2) Fe-Complex (4) Fe-Complex (1). This order was familiar with the strength of H-bonding responsible for interaction with DNA and consistent with suggested geometries of the complexes. Additionally, the above intrinsic binding constant values indicate that the binding affinity of the complexes bearing Schiff bases with methoxy substituents is stronger than that of the ligand bearing N-dimethyl substituents.
Further, the newly synthesized ligands and their metal complexes were tested for their antioxidant activities. Based on the comparison of the IC50 values of the samples ranked in the following order: L2 > L1 > Ni-Complex (5) > Ni-Complex (2) > Cu-Complex (6) > Cu-Complex (3) > Fe-Complex (4) > Fe-Complex (1). Those data were consistent with the ability of scavenger to donate electrons to screen free radical. The lower IC50 values observed in antioxidant assays demonstrate that the investigated compounds have a strong potential relative to the natural antioxidant ascorbic acid, which allow the possibility of using them as scavengers to eliminate the radicals.