الفهرس 
Part I: General IntroductionOnly 14 pages are availabe for public view
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Abstract
”This thesis is devoted to the development of new analytical methods for the determination of some pharmaceutical compounds containing heterocyclic rings. The developed methods can be applied for the routine analysis of the studied compounds in quality control laboratories in pharmaceutical companies and bioequivalence centers. The thesis comprises eight main parts: Part I: This part comprises a general introduction about heterocyclic compounds including their history, general features, biological significance, and applications. Part II: This part aimed to develop a simple synchronous spectrofluorimetric method for the determination of ponatinib and curcumin. This method allows the simultaneous determination of ponatinib and curcumin in presence of each other without interference, using Δ λ of 160 nm. The developed methods were efficiently applied for the estimation of the studied drugs in spiked human plasma samples with high % recoveries. Part III: The objective of this work was to develop a novel sensitive, green method for simultaneous quantification of favipiravir and hydroxychloroquine in their tablets and in biological fluids. The method is based on synchronous spectrofluorimetric method for simultaneous determination of favipiravir and hydroxychloroquine in presence of each other without interference, using Δ λ of 60 nm. The method was efficiently applied for the estimation of the studied drugs in spiked human plasma samples with high % recoveries. Part IV: The purpose of this study was to provide a green synchronous spectrofluorimetric method for quantification of remdesivir and simprevir in the presence of one another, without any observed interference, by using a wavelength difference (Δ λ) of 90 nm. The developed method demonstrated excellent efficiency in estimating the studied drugs mentioned in spiked human plasma samples with acceptable % recoveries. Part V: This part was devoted to the development and validation of a sensitive spectrofluorimetric method for the determination of piroxicam (PRX), tenoxicam (TNX) and lornoxicam (LRX) in pharmaceutical formulations and/or biological fluids directly without prior derivatization for the first time. The developed method depends on the simple preparation of N,S-CQDs by hydrothermal treatment of citric acid and thiosemicarbazide. The developed method was applied for the determination of PRX, TNX and LRX in raw materials and pharmaceutical formultions and extended to determination of PRX in spiked human plasma with high % recoveries. Part VI: The current method aimed to develop and validate a sensitive spectrofluorimetric method for the determination of nitrofurantoin (NFT) and dantrolene (DTL) in different pharmaceutical dosage form and /or biological fluids using N,S-CQDs directly without prior derivatization for the first time. The developed method was applied for the determination of NFT and DTL in raw materials and extended to their determination in pharmaceutical dosage form and/or biological fluids with high % recoveries. Part VII: The aim of the suggested work was to propose facile and sensitive spectrophotometric and spectrofluorimetric methods for the estimation of sunitinib (SUN) in different matrices. The methods depended on the association complex formed between EB and SUN in Britton Robinson buffer (pH 4). The formed complex was found to have λmax at 555 nm. Also, the native fluorescence of EB was found to be quenched upon the addition of SUN at λem 550 nm after excitation at 528 nm. The proposed methods successfully quantified SUN in raw material and spiked human plasma. ICH guidelines were utilized to validate both methods.Part VIII: A novel analytical high-performance liquid chromatography (HPLC) approach was developed using a full factorial design. This method allows for the simultaneous determination of trimethoprim, sulphamethoxazole and phenytoin in spiked human plasma. The objective is to achieve the most optimal analytical performance by simultaneously varying multiple variables, as instead of altering a single variable at a time. Satisfactory results regarding the different validation parameters of the analytes were obtained according to ICH and US FDA guidelines for bioanalytical methods.