الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Stroke is a prevalent neurological disorder and the second leading cause of death and disability worldwide. Platelets play a crucial role in the pathophysiology of atherosclerosis, inflammation, and thrombosis. Platelet indices such as mean platelet volume (MPV) and platelet distribution width (PDW), have been proposed as biomarkers for various diseases. Elevated MPV and PDW levels have been linked to increased platelet activation, aggregation, adhesion, and prothrombotic events. We prospectively studied100 patients aged 18–85 years from Mansoura University Hospitals with acute ischemic strokesand a similar of healthy subjects as a control group over a year, between January 2022 and February 2023. The diagnosis of acute ischemic stroke was based on clinical symptoms. The majority of strokes were supratentorial, with symptoms such as facial droop, arm drop, speech disturbances, and time disturbances. Neurologic assessments were performed using the NIHSS scorefor classifying patients stroke severity, mRS for patient’s functional outcomes at three months after onset of stroke symptoms and TOAST classification system. Additionally, radiologically brain CT scan applied ASPECTS for anterior and posterior circulation strokes. Laboratory investigations included a complete blood count, platelet indices, and lipid profile. The Mean Platelet Volume (MPV) is the average size of platelets in the blood sample. The Platelet Distribution Width (PDW) measures the variation in the size of platelets .The study aimed to evaluate the effects of these factors on stroke severity and outcomes. Our study found that hypertension, dyslipidemia, and diabetes were the most common riskfactors for stroke. Platelet indices, lipid profiles, and stroke severity were significantly correlated with higher MPV and PLR levels in stroke cases compared to controls. Cholesterol, triglyceride, HDL, and LDL levels were also significantly higher in stroke cases, suggesting dyslipidemia may be a contributing factor. The severity of stroke was significantly influenced by its cause, with cardioembolic causes associated with the highest severity. Lower MPV and higher PLR and LDL levels were associated with worse outcomes, suggesting their potential role as prognostic biomarkers for ischemic stroke. Conclusion. The present study aimed to investigate the association between platelet indices, lipid profile, and stroke severity and outcome in patients with acute ischemic stroke. The study highlights the potential role of platelet indices and LDL levels in predicting stroke severity and functional outcomes. In our study, we concluded that platelet indices, as well as LDL, and TC were significantly higher among stroke patients than the control group. In addition, LDL and PDW, and PLR were significantly associated with patient’s mortality, outcome, as well as the severity of stroke. Moreover, among all stroke causes, patients with CE had the highest severity score.