الفهرس 
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Abstract
Nowadays, infectious diarrhea in dogs and cats is one of the most common maladies facing veterinarians. This study discussed the prevalence of some enteropathogenic E. coli and Klebsiella pneumoniae as well as their virulence genes. Fecal samples were collected from 180 diarrheic dogs and 70 diarrheic cats admitted to veterinary clinics at Cairo. The antimicrobial susceptibility profiles of the isolates were assayed. The obtained results showed that dogs and cats harbor enteropathogenic E. coli with incidences of 42% (75/180) and 40 % (28/70), respectively. Meanwhile, K. pneumoniae incidences were 21% (37/180) and 13 % (9/70) in dogs and cats, respectively. Antimicrobial sensitivity of the examined isolates revealed that E. coli isolates from dogs and cats were highly resistant to ampicillin/sulbactam (68% and 79%), ampicillin (59% and 64%) and amoxicillin /clavulanic acid (49 % and 54%), respectively. K. pneumoniae isolates, from dogs and cats, were highly resistant to ceftazidime (100%, and 100%), ampicillin(78% and 88%), amikacin (78% and 67%), amoxicillin /clavulanic acid (62% and 67%), respectively. pathogenic E. coli and K. pneumoniae isolates proved high frequency of virulence genes as ompA, vt2e, eaeA, LT, STa, cnf1, mrkA, ecpA, fimA, fimH. This was combined with diarrhea at different ages with possible active transmission to contacting humans, which represents an escalating potential public health hazard.