الفهرس 
Title : Relationship between Metabolic Syndrome and Uric Acid Levels in Egyptian children with Familial Mediterranean Fever
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Abstract
Background: Familial Mediterranean Fever (FMF) is the most frequent periodic febrile syndrome among the autoinflammatory syndromes. Metabolic syndrome (MetS) is receiving greater attention from public health decision makers and physicians. Recently, hyperuricemia has been shown to play a role in MetS pathophysiology. Whether serum uric acid can be used as a marker for metabolic syndrome is still controversial.
Rheumatic diseases may be risk factors for atherosclerosis. Several studies have shown that FMF might be a risk factor for early atherosclerosis because of its inflammatory nature. It is also believed that a mutation in MEFV gene may increase the prevalence of Metabolic syndrome by increasing the release of inflammatory markers (e.g., IL-1β, TNF-α) in patients with FMF more actively in the active period, but also in the subclinical period.
Objectives: The aim of this study was to detect prevalence of metabolic syndrome in Egyptian children with familial Mediterranean fever and its correlation with serum uric acid level.
Patients and methods: Our study was a case control observational study included 80 children (40 children with FMF and 40 apparently healthy age and sex matched children as control). The study was conducted in Rheumatology and Endocrinology clinics, Children Hospital, Cairo University. Patients were recruited from Rheumatology clinic. Both groups were subjected to full history taking, clinical examination and laboratory evaluation.
Results: Our study shows that there was a statistically significant difference regarding insulin resistance in cases and control groups where 60% of the cases had insulin resistance while 35% of control group had insulin resistance. Also, regarding serum uric acid level, it was significantly higher in cases than in control group. There were neither patients nor control that fulfilled criteria of metabolic syndrome.