الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Laparoscopic procedures have gained widespread acceptance due to their demonstrated benefits, including quicker postoperative recovery, reduced rates of postoperative complications, and early discharge. Postoperative pain experienced by patients undergoing laparoscopic procedures may impede the viability of ambulatory laparoscopic cholecystectomy.
Dexmedetomidine is a selective α2 agonist used in anaesthesia that provides dose-dependent sedation, anxiolysis, and analgesia without affecting respiration. It has a shorter duration of action hence a short side effect profile when compared to clonidine.
This prospective, double-blind, randomized controlled study was carried out at Beni Suef University hospital and involved 135 patients (18-60 years old, ASA physical status I or II, both genders) undergoing elective laparoscopic cholecystectomy under general anesthesia.
This study evaluated the effectiveness of adding intraperitoneal dexmedetomidine (1 mcg/kg or 0.5 mcg/kg) to bupivacaine (125 mg) for postoperative analgesia in patients undergoing elective laparoscopic cholecystectomy under general anaesthesia. It also assesses the safety of this combination in the first 24 hours after surgery.
The results showed that the group receiving the combination of 1 mcg/kg of intraperitoneal dexmedetomidine and 125 mg of bupivacaine (when compared to 0.5 mcg/kg of intraperitoneal dexmedetomidine and 125 mg of bupivacaine or bupivacaine as sole agent) had better postoperative outcomes, including stable hemodynamic parameters, improved VAS scores, decreased need for postoperative analgesia, and a longer duration until analgesia was requested.
The study findings concluded that combining intraperitoneal dexmedetomidine and bupivacaine provides effective postoperative pain management in laparoscopic cholecystectomy patients and enhanced postoperative outcomes. However, there was no significant effect on intraoperative hemodynamics or surgical analgesic needs with the use of dexmedetomidine.
Further research with larger sample sizes is necessary to further investigate the analgesic effects of intraperitoneal agents. Future studies should explore not only the potential benefits of these agents but also examine any potential adverse effects.